[HTML][HTML] Extracellular vesicle-loaded hydrogels for tissue repair and regeneration

Y Ju, Y Hu, P Yang, X Xie, B Fang - Materials Today Bio, 2023 - Elsevier
Extracellular vesicles (EVs) are a collective term for nanoscale or microscale vesicles
secreted by cells that play important biological roles. Mesenchymal stem cells are a class of …

[HTML][HTML] Therapeutic potential and mechanisms of mesenchymal stem cell-derived exosomes as bioactive materials in tendon–bone healing

J Zou, W Yang, W Cui, C Li, C Ma, X Ji, J Hong… - Journal of …, 2023 - Springer
Tendon–bone insertion (TBI) injuries, such as anterior cruciate ligament injury and rotator
cuff injury, are the most common soft tissue injuries. In most situations, surgical …

[HTML][HTML] Exosome nanovesicles: a potential carrier for therapeutic delivery

VP Chavda, A Pandya, L Kumar, N Raval, LK Vora… - Nano Today, 2023 - Elsevier
Exosomes are small nanosized biovesicles that form when multivesicular bodies and the
plasma membrane fuse and are released into the surrounding body fluids. They are best …

[HTML][HTML] Carcinoma-associated fibroblasts promote the stemness and chemoresistance of colorectal cancer by transferring exosomal lncRNA H19

J Ren, L Ding, D Zhang, G Shi, Q Xu, S Shen… - Theranostics, 2018 - ncbi.nlm.nih.gov
Long non-coding RNAs (lncRNAs) are involved in the pathology of various tumors, including
colorectal cancer (CRC). The crosstalk between carcinoma-associated fibroblasts (CAFs) …

[HTML][HTML] Adipose-derived stem cells secretome and its potential application in “stem cell-free therapy”

A Trzyna, A Banaś-Ząbczyk - Biomolecules, 2021 - mdpi.com
Adipose-derived stem cells (ASCs) secrete many cytokines, proteins, growth factors, and
extracellular vesicles with beneficial outcomes that can be used in regenerative medicine. It …

Engineering mesenchymal stem cells to improve their exosome efficacy and yield for cell-free therapy

J Phan, P Kumar, D Hao, K Gao… - Journal of extracellular …, 2018 - Taylor & Francis
Through traditional medicine, there were diseases and disorders that previously remained
untreated or were simply thought to be incurable. Since the discovery of mesenchymal stem …

Intranasal delivery of mesenchymal stem cell-derived extracellular vesicles exerts immunomodulatory and neuroprotective effects in a 3xTg model of Alzheimer's …

M Losurdo, M Pedrazzoli, C D'Agostino… - Stem cells …, 2020 - academic.oup.com
The critical role of neuroinflammation in favoring and accelerating the pathogenic process in
Alzheimer's disease (AD) increased the need to target the cerebral innate immune cells as a …

[HTML][HTML] Identification of RNA-binding proteins in exosomes capable of interacting with different types of RNA: RBP-facilitated transport of RNAs into exosomes

L Statello, M Maugeri, E Garre, M Nawaz, J Wahlgren… - PloS one, 2018 - journals.plos.org
The RNA that is packaged into exosomes is termed as exosomal-shuttle RNA (esRNA);
however, the players, which take this subset of RNA (esRNA) into exosomes, remain largely …

[HTML][HTML] Exosomal LncRNA LINC00659 transferred from cancer-associated fibroblasts promotes colorectal cancer cell progression via miR-342-3p/ANXA2 axis

L Zhou, J Li, Y Tang, M Yang - Journal of translational medicine, 2021 - Springer
Abstract Background Cancer-associated fibroblasts (CAFs) play a pivotal role in regulating
tumor progression by transferring exosomes to adjacent cells. Our aim was to clarify the role …

[HTML][HTML] Manufacturing and characterization of extracellular vesicles from umbilical cord–derived mesenchymal stromal cells for clinical testing

E Rohde, K Pachler, M Gimona - Cytotherapy, 2019 - Elsevier
Extracellular vesicles (EVs) derived from mesenchymal stromal cells (MSCs) may deliver
therapeutic effects that are comparable to their parental cells. MSC-EVs are promising …