[HTML][HTML] Anti-cancer activity of phytochemicals targeting hypoxia-inducible factor-1 alpha
BD Yun, SW Son, SY Choi, HJ Kuh, TJ Oh… - International Journal of …, 2021 - mdpi.com
Hypoxia-inducible factor-1 alpha (HIF-1α) is overexpressed in cancer, leading to a poor
prognosis in patients. Diverse cellular factors are able to regulate HIF-1α expression in …
prognosis in patients. Diverse cellular factors are able to regulate HIF-1α expression in …
[HTML][HTML] HIF‑1α: Its notable role in the maintenance of oxygen, bone and iron homeostasis
X Huang, Y Zhang, B Qi, K Sun… - International …, 2022 - spandidos-publications.com
Hypoxia is a characteristic feature of numerous diseases, including metabolic bone disease,
solid tumors, cardiovascular diseases, neurodegeneration and inflammation. It is also a risk …
solid tumors, cardiovascular diseases, neurodegeneration and inflammation. It is also a risk …
Design, synthesis and biological evaluation of sulfamoylphenyl-quinazoline derivatives as potential EGFR/CAIX dual inhibitors
B Zhang, Z Liu, S Xia, Q Liu, S Gou - European Journal of Medicinal …, 2021 - Elsevier
Multi-target, especially dual-target, drug design has become a popular research field for
cancer treatment. Development of small molecule dual-target inhibitors through …
cancer treatment. Development of small molecule dual-target inhibitors through …
Enantioselective Total Synthesis of (+)-Stephadiamine
B Yang, G Li, Q Wang, J Zhu - Journal of the American Chemical …, 2023 - ACS Publications
An asymmetric synthesis of (+)-stephadiamine has been accomplished featuring (a) an
enantioselective dearomatizative Michael addition to generate a quaternary stereocenter;(b) …
enantioselective dearomatizative Michael addition to generate a quaternary stereocenter;(b) …
Manassantin A inhibits tumour growth under hypoxia through the activation of chaperone-mediated autophagy by modulating Hsp90 activity
Background Chaperon-mediated autophagy (CMA) has taken on a new emphasis in cancer
biology. However, the roles of CMA in hypoxic tumours are poorly understood. We …
biology. However, the roles of CMA in hypoxic tumours are poorly understood. We …
[PDF][PDF] Activation of Chaperon-Mediated Autophagy Via Modulation of Hsp90 Activity Inhibits Tumor Growth Under Hypoxia
Background: Chaperon-mediated autophagy (CMA) is a target speci c degradation pathway
among autophagic processes. Although CMA plays critical roles in tumor progression in …
among autophagic processes. Although CMA plays critical roles in tumor progression in …