Replication stress is a major cause of genomic instability and a crucial vulnerability of
cancer cells. This vulnerability can be therapeutically targeted by inhibiting kinases that …

In 2014, FIGO's Committee for Gynecologic Oncology revised the staging of ovarian cancer,
incorporating ovarian, fallopian tube, and peritoneal cancer into the same system. Most of …

Ovarian carcinoma is characterized by heterogeneity at the molecular, cellular and
anatomical levels, both spatially and temporally. This heterogeneity affects response to …

Both cisplatin‐based chemotherapy and immune checkpoint blockers (ICBs)‐based
immunotherapy are the first‐line treatments for patients with advanced bladder cancer …

Importance Platinum-based chemotherapy has been the standard of care for ovarian cancer
for the past 3 decades. Although most patients respond to platinum-based treatment …

PURPOSE Preclinical cancer models harboring CCNE1 amplification were more sensitive to
adavosertib treatment, a WEE1 kinase inhibitor, than models without amplification. Thus, we …

DNA damage response (DDR) is critical to ensure genome stability, and defects in this
signaling pathway are highly associated with carcinogenesis and tumor progression …

PURPOSE Outcomes in RAS-mutant metastatic colorectal cancer (mCRC) remain poor and
patients have limited therapeutic options. Adavosertib is the first small-molecule inhibitor of …

DNA damage tolerance and mutagenesis are hallmarks and enabling characteristics of
neoplastic cells that drive tumorigenesis and allow cancer cells to resist therapy. The 'Y …

The replication stress response (RSR) involves a downstream kinase cascade comprising
ataxia telangiectasia-mutated (ATM), ATM and rad3-related (ATR), checkpoint kinases 1 and …