Senile osteoporosis has become a worldwide bone disease with the aging of the world
population. It increases the risk of bone fracture and seriously affects human health. Unlike …

We present an overview of Runx involvement in regulatory mechanisms that are requisite for
fidelity of bone cell growth and differentiation, as well as for skeletal homeostasis and the …

Epigenetic control of gene expression is critical for normal fetal development. However,
chromatin-related mechanisms that activate bone-specific programs during osteogenesis …

Osteoporosis is a metabolic disease characterized by decreased bone mineral density and
the destruction of bone microstructure, which can lead to increased bone fragility and risk of …

Osteoblasts produce calcified bone matrix and contribute to bone formation and remodeling.
In this study, we established a procedure to directly convert human fibroblasts into …

Epigenetic aberrations and cancer | Molecular Cancer Skip to main content SpringerLink
Account Menu Find a journal Publish with us Track your research Search Cart 1.Home 2.Molecular …

Stem cells are characterized by their capability to self‐renew and terminally differentiate into
multiple cell types. Somatic or adult stem cells have a finite self‐renewal capacity and are …

Bone metabolism consists of a balance between bone formation and bone resorption, which
is mediated by osteoblast and osteoclast activity, respectively. In order to ensure bone …

Altered gene expression in tumors can be caused by copy number alterations to DNA or
mutation affecting coding or regulatory regions of genes. However, epigenetic events may …

Epigenetic modifications play a central role in cell differentiation and development. In the
current study, we have recognized lysine demethylase 4A (KDM4A) as a novel epigenetic …