Transcriptional regulators related to the invertebrate sexual regulators doublesex and mab-3
occur throughout metazoans and control sex in most animal groups. Seven of these DMRT …

Forebrain development in vertebrates is regulated by transcription factors encoded by
homeobox, bHLH and forkhead gene families throughout the progressive and overlapping …

In the developing cerebral cortex, how progenitors that seemingly display limited diversity
end up producing a vast array of neurons remains a puzzling question. The prevailing model …

Elucidating the genetic control of cerebral cortical (pallial) development is essential for
understanding function, evolution, and disorders of the brain. Transcription factors (TFs) that …

The cortical hem, a source of Wingless-related (WNT) and bone morphogenetic protein
(BMP) signaling in the dorsomedial telencephalon, is the embryonic organizer for the …

Glioblastoma (GBM) is the most common and lethal brain tumor in adults. Due to its fast
proliferation, diffusive growth and therapy resistance survival times are less than two years …

The CreER/LoxP system is widely accepted to track neural lineages and study gene
functions upon tamoxifen (TAM) administration. We have observed that prenatal TAM …

Tangential migration is a mode of cell movement, which in the developing cerebral cortex, is
defined by displacement parallel to the ventricular surface and orthogonal to the radial glial …

We uncovered a transcription factor (TF) network that regulates cortical regional patterning
in radial glial stem cells. Screening the expression of hundreds of TFs in the developing …

The seat of human intelligence is the human cerebral cortex, which is responsible for our
exceptional cognitive abilities. Identifying principles that lead to the development of the large …