Store-operated calcium (Ca2+) entry (SOCE) occurs through a widely distributed family of
ion channels activated by the loss of Ca2+ from the endoplasmic reticulum (ER). The best …

Ca2+ signaling is ubiquitous in eukaryotic cells and modulates many cellular events
including cell migration. Directional cell migration requires the polarization of both signaling …

Communication and material transfer between membranes and organelles take place at
membrane contact sites (MCSs). MCSs between the ER and PM, the ER/PM junctions, are …

ER-PM junctions are membrane contact sites formed by the endoplasmic reticulum (ER) and
plasma membrane (PM) in close apposition together. The formation and stability of these …

Mucociliary clearance is a primary defence mechanism of the airways consisting of two
components, ciliary beating and transepithelial ion transport (ISC). Specialised …

Abstract Store-operated Ca2+ entry (SOCE) mediates the increase in intracellular calcium
(Ca2+) in endothelial cells (ECs) that regulates several EC functions including tissue-fluid …

Increases in cytosolic Ca2+ concentration regulate diverse cellular activities and are usually
evoked by opening of Ca2+ channels in intracellular Ca2+ stores and the plasma …

The calcium-release-activated calcium (CRAC) channel, activated by the release of Ca2+
from the endoplasmic reticulum (ER), is critical for Ca2+ homeostasis and active signal …

Store‐operated Ca2+ entry is a mechanism controlled by the filling state of the intracellular
Ca2+ stores, predominantly the endoplasmic reticulum (ER), where ER‐resident proteins …

Endoplasmic reticulum-plasma membrane contact sites (ER-PM MCS) are a specialised
domain involved in the control of Ca 2+ dynamics and various Ca 2+-dependent cellular …