Packaging of eukaryotic genome into chromatin is a major obstacle to cells encountering
DNA damage caused by external or internal agents. For maintaining genomic integrity, the …

Aging and age-related diseases pose some of the most significant and difficult challenges to
modern society as well as to the scientific and medical communities. Biological aging is a …

Eukaryotic cells package their genomes around histone octamers. In response to DNA
damage, checkpoint activation in yeast induces core histone degradation resulting in 20 …

Dot1 (disruptor of telomeric silencing-1, DOT1L in humans) is the only known enzyme
responsible for histone H3 lysine 79 methylation (H3K79me) and is evolutionarily conserved …

In budding yeast, a single DNA double-strand break (DSB) triggers the activation of Mec1
ATR-dependent DNA damage checkpoint. After about 12 h, cells turn off the checkpoint …

Double-strand breaks (DSBs) of DNA in eukaryotic cells are predominantly repaired by non-
homologous end joining (NHEJ). The histone chaperone anti-silencing factor 1a (ASF1a) …

The DNA damage checkpoint is a highly conserved signaling pathway induced by genotoxin
exposure or endogenous genome stress. It alters many cellular processes such as arresting …

Anti-silencing function 1a (ASF1a) is a histone H3–H4 chaperone isoform involved in
chromatin assembling and transcription regulation. Recently, ASF1a has been shown to be …

Proliferating cells coordinate histone and DNA synthesis to maintain correct stoichiometry for
chromatin assembly. Histone mRNA levels must be repressed when DNA replication is …

Single ribonucleoside monophosphates (rNMPs) are transiently present in eukaryotic
genomes. The RNase H2-dependent ribonucleotide excision repair (RER) pathway ensures …