Through their many and varied metabolic functions, mitochondria power life. Paradoxically,
mitochondria also have a central role in apoptotic cell death. Upon induction of …

Recent evidence supports the notion that mitochondrial metabolism is necessary for the
determination of stem cell fate. Historically, mitochondrial metabolism is linked to the …

Cellular metabolism in hematopoietic stem cells (HSCs) is an area of intense research
interest, but the metabolic requirements of HSCs and their adaptations to their niches during …

While the understanding of the genomic aberrations that underpin chronic and acute
myeloid leukaemia (CML and AML) has allowed the development of therapies for these …

Quiescence is a fundamental property that maintains hematopoietic stem cell (HSC) potency
throughout life. Quiescent HSCs are thought to rely on glycolysis for their energy, but the …

Summary N 6-methyladenosine (m 6 A) on mRNA plays critical roles in various cellular
processes. However, the landscape and dynamics of m 6 A modification in hematopoietic …

Hematopoietic stem cells (HSCs) have a number of unique physiologic adaptations that
enable lifelong maintenance of blood cell production, including a highly regulated rate of …

Metabolism has emerged as a key regulator of stem cell behavior. Mitochondria are crucial
metabolic organelles that are important for differentiated cells, yet considered less so for …

Hematopoietic stem cell transplantation is an effective regenerative therapy for many
malignant, inherited, or autoimmune diseases. However, our understanding of reconstituted …

Hematopoietic stem cells (HSCs) support haematopoiesis throughout life and give rise to the
whole variety of cells of the immune system. Developing in the early embryo, passing …