In this review, we present the basic properties, physiological functions, regulation, and
pathological alterations of four major classes of K+ channels that have been detected in …

The term endothelium-derived hyperpolarising factor (EDHF) was introduced in 1987 to
describe the hypothetical factor responsible for myocyte hyperpolarisations not associated …

Previous studies have indicated that curcumin supplementation may be beneficial for
cardiometabolic health; however, current evidence regarding the effects of its nanorange …

Potassium ion (K+) channel activity is a major regulator of vascular muscle cell membrane
potential (E m) and is therefore an important determinant of vascular tone. There is growing …

Our view of the endothelium was transformed around 30 years ago, from one of an inert
barrier to that of a key endocrine organ central to cardiovascular function. This dramatic …

Neuronal activity in the central nervous system evokes localized changes in blood flow, a
response termed neurovascular coupling or functional hyperaemia. Modern functional …

There are seven sub-families of Kir channels (Table 1), many of which have several
members. The sub-families are denoted Kit1. 0 to Kit7. 0 in the nomenclature introduced by …

Publisher Summary This chapter discusses the local control of microvascular perfusion,
which has been described as “the maintenance of appropriate tissue blood flow despite …

Cerebrovascular insults are a leading cause of brain injury in premature infants, contributing
to the high prevalence of motor, cognitive, and behavioral deficits. Understanding the …

Background and Purpose—Extracellular concentration of potassium ion ([K+] o) may have a
significant influence on the cerebral circulation in health and disease. Mechanisms of [K+] o …