Crosstalk between long non-coding RNAs, micro-RNAs and mRNAs: deciphering molecular mechanisms of master regulators in cancer

E López-Urrutia, LP Bustamante Montes… - Frontiers in …, 2019 - frontiersin.org
Cancer is a complex disease, and its study requires deep understanding of several
biological processes and their regulation. It is an accepted fact that non-coding RNAs are …

Mechanisms of taxane resistance

SM Maloney, CA Hoover, LV Morejon-Lasso… - Cancers, 2020 - mdpi.com
Simple Summary Drug resistance is prevalent in many types of cancer and decreases
patient survival. The taxanes are anti-mitotic chemotherapeutic agents, widely used since …

CircRNAs in anticancer drug resistance: recent advances and future potential

T Xu, M Wang, L Jiang, L Ma, L Wan, Q Chen, C Wei… - Molecular cancer, 2020 - Springer
CircRNAs are a novel class of RNA molecules with a unique closed continuous loop
structure. CircRNAs are abundant in eukaryotic cells, have unique stability and tissue …

Current progresses and challenges of immunotherapy in triple-negative breast cancer

K Mediratta, S El-Sahli, V D'Costa, L Wang - Cancers, 2020 - mdpi.com
Simple Summary The breakthrough of immunotherapy in melanoma has generated a
glimmer of hope for lethal triple negative breast cancer (TNBC). This review summarizes the …

Crosstalk between long noncoding RNA and microRNA in Cancer

R Bhattacharjee, N Prabhakar, L Kumar… - Cellular Oncology, 2023 - Springer
Abstract miRNAs and lncRNAs play a central role in cancer-associated gene regulations.
The dysregulated expression of lncRNAs has been reported as a hallmark of cancer …

Long Non-Coding RNA HOTAIR in Breast Cancer Therapy

M Cantile, M Di Bonito, M Cerrone, F Collina… - Cancers, 2020 - mdpi.com
Breast cancer (BC) is the most common cancer type among women, and morbidity and
mortality rates are still very high. Despite new innovative therapeutic approaches for all BC …

Disease-causing mutations and rearrangements in long non-coding RNA gene loci

M Aznaourova, N Schmerer, B Schmeck… - Frontiers in …, 2020 - frontiersin.org
The classic understanding of molecular disease-mechanisms is largely based on protein-
centric models. During the past decade however, genetic studies have identified numerous …

A novel cuproptosis-related lncRNA nomogram to improve the prognosis prediction of gastric cancer

A Feng, L He, T Chen, M Xu - Frontiers in oncology, 2022 - frontiersin.org
Background Cuproptosis is a copper-triggered modality of mitochondrial cell death and
cuproptosis process may play important roles in gastric cancer development. However, little …

[HTML][HTML] Long non-coding RNAs: functional regulatory players in breast cancer

RA Youness, MZ Gad - Non-coding RNA research, 2019 - Elsevier
Historically, the long-held protein-centered bias has denoted 98% of the human genome as
'Junk'DNA. However, the current work has shifted the perception of such'junk'transcriptional …

Enhancer-driven lncRNA BDNF-AS induces endocrine resistance and malignant progression of breast cancer through the RNH1/TRIM21/mTOR cascade

X Lin, X Dinglin, S Cao, S Zheng, C Wu, W Chen, Q Li… - Cell reports, 2020 - cell.com
Epigenomic alterations can give rise to various tumor-promoting properties, including
therapeutic resistance of cancer cells. Here, we identify an lncRNA, BDNF-AS, whose …