The pandemic of coronavirus disease 2019 (COVID-19) and its pathogen, severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2) have become the greatest current threat …

Hypoxia-inducible factors (HIFs) are highly conserved transcription factors that are crucial for
adaptation of metazoans to limited oxygen availability. Recently, HIF activation and …

Cardiac function is required for blood circulation and systemic oxygen delivery. However,
the heart has intrinsic oxygen demands that must be met to maintain effective contractility …

Acute renal failure resulting from hypoperfusion and hypoxia is a significant clinical problem.
Hypoxia activates the heterodimeric transcription factor hypoxia inducible factor (HIF) …

This article outlines the need for a homeostatic response to alterations in cellular
oxygenation. It describes work on erythropoietin control that led to the discovery of the …

Abstract Aims Hypoxia-inducible factor-1 (HIF-1) has been reported to promote tolerance
against acute myocardial ischaemia–reperfusion injury (IRI). However, the mechanism …

Hypoxia-inducible factor (HIF) is the principal transcription factor involved in the regulation of
transcriptional responses to hypoxia. During hypoxia, HIF-α levels accumulate and trigger …

Increasing evidence indicates that stimulating hippocampal neurogenesis could provide
novel avenues for the treatment of depression, and recent studies have shown that in vitro …

Hypoxia inducible factors (HIFs) are α/β heterodimeric transcription factors that direct
multiple cellular and systemic responses in response to changes in oxygen availability. The …

Since its discovery in early 1990s, hypoxia inducible factor 1 (HIF-1) has been increasingly
recognized for its key role in transcriptional control of more than a hundred genes that …