Fragment ion intensity prediction improves the identification rate of non-tryptic peptides in timsTOF

C Adams, W Gabriel, K Laukens, M Picciani… - Nature …, 2024 - nature.com
Immunopeptidomics is crucial for immunotherapy and vaccine development. Because the
generation of immunopeptides from their parent proteins does not adhere to clear-cut rules …

Liquid-phase separations coupled with ion mobility-mass spectrometry for next-generation biopharmaceutical analysis

DM Makey, BT Ruotolo - Expert Review of Proteomics, 2024 - Taylor & Francis
Introduction The pharmaceutical industry continues to expand its search for innovative
biotherapeutics. The comprehensive characterization of such therapeutics requires many …

Proteomics—The State of the Field: The Definition and Analysis of Proteomes Should Be Based in Reality, Not Convenience

JR Coorssen, MP Padula - Proteomes, 2024 - mdpi.com
With growing recognition and acknowledgement of the genuine complexity of proteomes, we
are finally entering the post-proteogenomic era. Routine assessment of proteomes as …

Zero-shot retention time prediction for unseen post-translational modifications with molecular structure encodings

C Dens, O Krokhin, D Yeung, K Laukens, W Bittremieux - bioRxiv, 2024 - biorxiv.org
Mass spectrometry-based proteomics relies on accurate peptide property prediction models
to enhance peptide identification and characterization, especially when dealing with …

Bioinformatics approaches to unravel hidden knowledge from mass spectrometry-based proteomics data

C Adams - 2024 - repository.uantwerpen.be
Mass spectrometry is a powerful tool for identifying proteins and peptides from biological
samples. However, annotating the spectra from a mass spectrometry experiment can be …