Fibroblast Growth Factor Receptor (FGFR) signalling plays a critical role in breast embryonal
development, tissue homeostasis, tumorigenesis and metastasis. FGFR, its numerous FGF …

There are five fibroblast growth factor receptors (FGFRs), namely, FGFR1–FGFR5. When
FGFR binds to its ligand, namely, fibroblast growth factor (FGF), it dimerizes and …

Klotho is a membrane-bound protein predominantly expressed in the kidney, where it acts
as a permissive co-receptor for Fibroblast Growth Factor 23. In its shed form, Klotho exerts …

Fibroblast growth factor receptor 4 (FGFR4), a tyrosine kinase receptor for FGFs, is involved
in diverse cellular processes, including the regulation of cell proliferation, differentiation …

Abstract αKlotho (Klotho), a type I transmembrane protein and a coreceptor for Fibroblast
Growth Factor-23, was initially thought to be expressed only in a limited number of tissues …

Fibroblast growth factor (FGF) receptor 4 (FGFR4) belongs to a family of tyrosine kinase
receptor. FGFR4 is highly activated in certain types of cancer and its activation is closely …

The fibroblast growth factor receptor (FGFR) signaling pathway has long been known to
cancer researchers because of its role in cell survival, proliferation, migration, and …

Together with fibroblast growth factors (FGFs) 19 and 21, FGF23 is an endocrine member of
the family of FGFs. Mainly secreted by bone cells, FGF23 acts as a hormone on the kidney …

Basal-like breast cancer is an aggressive tumor subtype with poor prognosis. The discovery
of underlying mechanisms mediating tumor cell survival, and the development of novel …

Although genetic amplification and overexpression of the fibroblast growth factor 19 (FGF19)
gene are found in human breast cancer, mechanisms that contribute to such functional …