Oxidative stress and endothelial dysfunction in sepsis and acute inflammation

J Joffre, J Hellman - Antioxidants & redox signaling, 2021 - liebertpub.com
Significance: Under homeostatic conditions, the endothelium dynamically regulates vascular
barrier function, coagulation pathways, leukocyte adhesion, and vasomotor tone. During …

Resuscitation fluids

JA Myburgh, MG Mythen - New England Journal of Medicine, 2013 - Mass Medical Soc
Resuscitation Fluids | New England Journal of Medicine Skip to main content Access provided
byTE WHATU ORA HEALTH NEW ZEALAND COUNTIES MANUKAU The New England …

DALI: defining antibiotic levels in intensive care unit patients: are current β-lactam antibiotic doses sufficient for critically ill patients?

JA Roberts, SK Paul, M Akova, M Bassetti… - Clinical infectious …, 2014 - academic.oup.com
Background. Morbidity and mortality for critically ill patients with infections remains a global
healthcare problem. We aimed to determine whether β-lactam antibiotic dosing in critically ill …

Cristaloides y coloides en la reanimación del paciente crítico

J Garnacho-Montero, E Fernández-Mondéjar… - Medicina intensiva, 2015 - Elsevier
La reanimación con fluidos es esencial para la supervivencia del paciente crítico en shock,
independientemente de la causa que lo origine. Hoy en día disponemos de diversos …

[HTML][HTML] The effect of pathophysiology on pharmacokinetics in the critically ill patient—concepts appraised by the example of antimicrobial agents

SI Blot, F Pea, J Lipman - Advanced drug delivery reviews, 2014 - Elsevier
Critically ill patients are at high risk for development of life-threatening infection leading to
sepsis and multiple organ failure. Adequate antimicrobial therapy is pivotal for optimizing the …

Intravenous fluid therapy in critically ill adults

S Finfer, J Myburgh, R Bellomo - Nature Reviews Nephrology, 2018 - nature.com
Intravenous fluid therapy is one of the most common interventions in acutely ill patients.
Each day, over 20% of patients in intensive care units (ICUs) receive intravenous fluid …

Hypoalbuminemia

A Gatta, A Verardo, M Bolognesi - Internal and emergency medicine, 2012 - Springer
Hypoalbuminemia is frequently observed in hospitalized patients and it can be associated
with several different diseases, including cirrhosis, malnutrition, nephrotic syndrome and …

Colloids versus crystalloids for fluid resuscitation in critically ill people

SR Lewis, MW Pritchard, DJW Evans… - Cochrane Database …, 2018 - cochranelibrary.com
Background Critically ill people may lose fluid because of serious conditions, infections (eg
sepsis), trauma, or burns, and need additional fluids urgently to prevent dehydration or …

A rational approach to perioperative fluid management

D Chappell, M Jacob, K Hofmann-Kiefer… - The Journal of the …, 2008 - pubs.asahq.org
Replacement of assumed preoperative deficits, in addition to generous substitution of an
unsubstantiated increased insensible perspiration and third space loss, plays an important …

The effects of hypoalbuminaemia on optimizing antibacterial dosing in critically ill patients

M Ulldemolins, JA Roberts, J Rello, DL Paterson… - Clinical …, 2011 - Springer
Low serum albumin levels are very common in critically ill patients, with reported incidences
as high as 40–50%. This condition appears to be associated with alterations in the degree of …