The enediynes are known for highly potent anticancer, antimicrobial, as well as cytotoxic
activities. The discovery of enediynes from natural sources was achieved in late 1980s. They …

Enediynes undergo a Bergman cyclization reaction to form the labile 1, 4‐didehy‐
drobenzene (p‐benzyne) biradical. The energetics of this reaction and the related Schreiner …

Natural enediyne antibiotics are powerful DNA-cleavage agents due to the presence of the
highly reactive hex-3-ene-1, 5-diyne units. However, the complicated chemical structure and …

Structures and chemical properties of enediynes, viz., compounds comprising a system of
conjugated double and triple bonds, are surveyed. The presence of this system in the …

Since the discovery of the role of enediynes in natural antibiotics (such as calicheamicines)
via in situ diradical-induced DNA strand cleavage, Bergman cyclization has attracted fervent …

Acetylene systems present a new route to cyclic compounds as an alternative to more
traditional methods employed in classical organic chemistry. The synthesis of cyclic …

The COGEF technique (COnstrained Geometries simulating External Force) was used to
investigate the effects of macroscopic forces on cyclic enediynes, which can undergo …

The enediyne moiety is a versatile functional group found in natural anticancer and anti-
infective agents, undergoing the Bergman cyclization reaction to afford a diradical which …

Incorporation of enediynes into anticancer drugs remains an intriguing yet elusive strategy
for the design of therapeutically active agents. Density functional theory was used to locate …

Three distinct classes of nucleobase-containing enediynes 1–9 with varying nature of the
linker have been synthesized to explore the effect of π-stacking interaction in accelerating …