Astrocytes, oligodendrocytes, and microglia are abundant cell types found in the central
nervous system and have been shown to play crucial roles in regulating both normal and …

Aging is a complex biological process that increases the risk of age-related cognitive
degenerative diseases such as dementia, including Alzheimer's disease (AD), Lewy Body …

Injury or insult to the adult nervous system often results in reactivation of signaling pathways
that are normally only active during development. The p75 neurotrophin receptor (p75 NTR) …

Stress has long been associated with the development of neuropsychiatric and neurological
disorders. The effects of stress vary depending upon the age during which the stress is …

Chronic neurodegenerative diseases represent major unmet needs for therapeutic
interventions. Recently, the neurocentric view of brain function and disease has been …

Neurotrophins and their respective tropomyosin related kinase (Trk) receptors (TrkA, TrkB,
and TrkC) and the p75 neurotrophin receptor (p75 NTR) play a fundamental role in the …

Abstract p75 NTR, the common receptor for both neurotrophins and proneurotrophins, has
been widely studied because of its role in many tissues, including the nervous system. More …

Learning and memory deficits are early clinical manifestations of Huntington's disease (HD).
These cognitive impairments have been mainly associated with frontostriatal HD pathology; …

Neuron–glia communication is essential for regulating the properties of synaptic
connections in the brain. Astrocytes, in particular, play a critical and complex role in synapse …

Tumor necrosis factor (TNF)-stimulated gene-6 (TSG-6) binds to hyaluronan and can
reorganize/stabilize its structure, also enhancing the binding of this glycosaminoglycan to its …