Neonatal hypoxia-ischaemia (HI) is the most common cause of death and disability in
human neonates, and is often associated with persistent motor, sensory, and cognitive …

The blood–brain barrier (BBB) is a highly specialized and dynamic compartment which
regulates the uptake of molecules and solutes from the blood. The relevance of the …

Hypoxic‐ischemic encephalopathy (HIE) is recognized as the main cause of neonatal death,
and efficient treatment strategies remain limited. Given the prevalence of HIE and the …

As clinicians attempt to understand the underlying reasons for the vulnerability of different
regions of the developing brain to injury, it is apparent that little is known as to how hypoxia …

Disorders of the developing brain represent a major health problem. The neurological
manifestations of brain lesions can range from severe clinical deficits to more subtle …

Although many attempts have been made, stroke treatment options are still extremely limited
and brain ischemia remains the leading cause of death and disability worldwide. Two major …

Cerebral edema, primarily caused by disruption of the blood-brain barrier (BBB), is one of
the serious complications associated with brain injury in neonatal hypoxic-ischemic …

Central nervous system homeostasis is maintained by cellular barriers that protect the brain
from external environmental changes and protect the CNS from harmful molecules and …

Background Hypoxic ischemic (HI) insults during pregnancy and birth can result in
neurodevelopmental disorders, such as cerebral palsy. We have previously shown that a …

Background: Hypoxic ischemic (HI) insult in term babies at labor or birth can cause long-
term neurodevelopmental disorders, including cerebral palsy (CP). The current standard …