Throughout the body, T cells monitor MHC-bound ligands expressed on the surface of
essentially all cell types. MHC ligands that trigger a T cell immune response are referred to …

Antigen presentation lies at the heart of immune recognition of infected or malignant cells.
For this reason, important efforts have been made to predict which peptides are more likely …

Post-translational modification (PTM) of antigens provides an additional source of
specificities targeted by immune responses to tumors or pathogens, but identifying antigen …

Identification of human leukocyte antigen (HLA)-bound peptides by liquid chromatography-
tandem mass spectrometry (LC-MS/MS) is poised to provide a deep understanding of rules …

Although mutations may represent attractive targets for immunotherapy, direct identification
of mutated peptide ligands isolated from human leucocyte antigens (HLA) on the surface of …

Predicting the binding affinity of major histocompatibility complex I (MHC I) proteins and their
peptide ligands is important for vaccine design. We introduce an open-source package for …

The precise identification of Human Leukocyte Antigen class I (HLA-I) binding motifs plays a
central role in our ability to understand and predict (neo-) antigen presentation in infectious …

Comprehensive knowledge of the human leukocyte antigen (HLA) class-I and class-II
peptides presented to T-cells is crucial for designing innovative therapeutics against cancer …

HLA-I molecules bind short peptides and present them for recognition by CD8+ T cells. The
length of HLA-I ligands typically ranges from 8 to 12 aa, but variability is observed across …

One third of humans are infected lifelong with the brain-dwelling, protozoan parasite,
Toxoplasma gondii. Approximately fifteen million of these have congenital toxoplasmosis …