Autophagy and endocytosis deliver unneeded cellular materials to lysosomes for
degradation. Beyond processing cellular waste, lysosomes release metabolites and ions …

Alzheimer's disease (AD) is a progressive neurodegenerative disorder that represents the
most common cause of dementia in the United States. Although the link between alcohol …

Departing from conventional narratives of the United States and the Americas as
fundamentally continental spaces, the contributors to Archipelagic American Studies …

Abstract Alzheimer's disease (AD), which is the most common type of dementia, is
characterized by the deposition of extracellular amyloid plaques. To understand the …

Alzheimer's disease (AD) is an incurable age-associated neurodegenerative disorder that is
characterized by irreversible progressive cognitive deficits and extensive brain damage. The …

The highly-interconnected and neurochemically-rich frontal cortex plays a crucial role in the
regulation of mood and cognition, domains disrupted in depression and other central …

Described here is the application of thermodynamic stability measurements to study age-
related differences in the folding and stability of proteins in a rodent model of aging …

The cerebral accumulation and cytotoxicity of amyloid beta (Aβ) is central to Alzheimer's
pathogenesis. However, little is known about how the amyloid pathology affects the global …

Memory loss is the most profound clinical manifestation in Alzheimer's disease (AD);
however, the molecular mechanisms underlying these deficits are poorly understood …

Aim. Diabetes with its associated hyperglycemia induces various type of peripheral damage
and also impairs the central nervous system (CNS). This study is aimed at clarifying the …