Structurally diverse G-quadruplexes as the noncanonical nucleic acid drug target for live cell imaging and antibacterial study

BX Zheng, J Yu, W Long, KH Chan… - Chemical …, 2023 - pubs.rsc.org
The formation of G-quadruplex structures (G4s) in vitro from guanine (G)-rich nucleic acid
sequences of DNA and RNA stabilized with monovalent cations, typically K+ and Na+, under …

Design mitochondria-specific fluorescent turn-on probes targeting G-quadruplexes for live cell imaging and mitophagy monitoring study

MT She, JW Yang, BX Zheng, W Long… - Chemical Engineering …, 2022 - Elsevier
A series of new mitochondrial-selective fluorescent probe was designed and synthesized
based on the integration of two planar molecular scaffolds of benzo-indole/indole with a p …

Rational design of self-quenched rhodamine dimers as fluorogenic aptamer probes for live-cell RNA imaging

KT Fam, R Pelletier, F Bouhedda… - Analytical …, 2022 - ACS Publications
With the growing interest in the understanding of the importance of RNAs in health and
disease, detection of RNAs in living cells is of high importance. Fluorogenic dyes that light …

Rationally Designed G-Quadruplex Selective “Turn-On” NIR Fluorescent Probe with Large Stokes Shift for Nucleic Acid Research-Based Applications

S Parveen, N Chaurasia, S Gupta… - ACS Applied Bio …, 2024 - ACS Publications
Guanine-rich DNA/RNA sequences can form Hoogsteen bonds to adopt noncanonical
secondary structures called G-quadruplexes, and these have been associated with diverse …

Illuminating the G-Quadruplex: A Review on Fluorescent Probes for Detecting Polymorphic G-Quartet DNA Structures

SK Ganegamage, MD Heagy - Current Organic Chemistry, 2022 - ingentaconnect.com
Modulating crucial biological processes such as gene regulation, aging, and relationship to
globally important human health issues such as cancer has significantly brought …

Structure-Informed Design of an Ultra Bright RNA-activated Fluorophore

JS Schneekloth Jr, M Yang, P Prestwood… - Research …, 2024 - pmc.ncbi.nlm.nih.gov
Fluorogenic RNAs such as the Mango aptamers are uniquely powerful tools for imaging
RNA. A central challenge has been to develop brighter, more specific, and higher affinity …

[图书][B] Design, Synthesis, and Characterization of Mechanosensitive Dual Fluorescent Dyes as Potential Probes for Biological Applications

SK Ganegamage - 2022 - search.proquest.com
Design, Synthesis, and Characterization of Mechanosensitive Dual Fluorescent Dyes as
Potential Probes for Biological Applications Abstract Dual fluorescence is a rare optical …