Osteosarcoma is one of the most common primary tumours of the bone, with a 5‐year
survival rate of less than 20% after the development of metastases. Osteosarcoma is highly …

As one of the most important natural materials, cortical bone is a composite material
comprising assemblies of tropocollagen molecules and nanoscale hydroxyapatite mineral …

Aging and bone diseases are associated with increased fracture risk. It is therefore pertinent
to seek an understanding of the origins of such disease-related deterioration in bone's …

Osteocytes, the most abundant bone cell in the adult skeleton, can function as
mechanosensors directing osteoblast and osteoclast function in order to maintain optimal …

Ageing and associated skeletal diseases pose a significant challenge for health care
systems worldwide. Age-related fractures have a serious impact on personal, social and …

Bone continuously adapts to its mechanical environment by structural reorganization to
maintain mechanical strength. As the adaptive capabilities of bone are portrayed in its nano …

Osteoporosis is characterised by trabecular bone loss resulting from increased osteoclast
activation and unbalanced coupling between resorption and formation, which induces a …

Type 1 collagen matrix volume, its degree of completeness of its mineralization, the extent of
collagen crosslinking and water content, and the non-collagenous proteins like osteopontin …

Bisphosphonates are a common treatment to reduce osteoporotic fractures. This treatment
induces osseous structural and compositional changes accompanied by positive effects on …

Bone fracture risk is influenced by bone quality, which encompasses bone's composition as
well as its multiscale organization and architecture. Aging and disease deteriorate bone …