[HTML][HTML] Phage therapy: From biological mechanisms to future directions

SA Strathdee, GF Hatfull, VK Mutalik, RT Schooley - Cell, 2023 - cell.com
Increasing antimicrobial resistance rates have revitalized bacteriophage (phage) research,
the natural predators of bacteria discovered over 100 years ago. In order to use phages …

Considerations for the use of phage therapy in clinical practice

GA Suh, TP Lodise, PD Tamma… - Antimicrobial agents …, 2022 - Am Soc Microbiol
Increasing antimicrobial resistance and medical device-related infections have led to a
renewed interest in phage therapy as an alternative or adjunct to conventional …

Microbiota's role in health and diseases

A El-Sayed, L Aleya, M Kamel - Environmental Science and Pollution …, 2021 - Springer
The microbiome is a term that usually refers to the community of various microorganisms that
inhabit/live inside human/animal bodies or on their skin. It forms a complex ecosystem that …

Engineered bacteriophage therapeutics: rationale, challenges and future

M Łobocka, K Dąbrowska, A Górski - BioDrugs, 2021 - Springer
The current problems with increasing bacterial resistance to antibacterial therapies, resulting
in a growing frequency of incurable bacterial infections, necessitates the acceleration of …

Pharmacologically aware phage therapy: pharmacodynamic and pharmacokinetic obstacles to phage antibacterial action in animal and human bodies

K Dąbrowska, ST Abedon - Microbiology and Molecular Biology …, 2019 - Am Soc Microbiol
The use of viruses infecting bacteria (bacteriophages or phages) to treat bacterial infections
has been ongoing clinically for approximately 100 years. Despite that long history, the …

A bacteriophage-based, highly efficacious, needle-and adjuvant-free, mucosal COVID-19 vaccine

J Zhu, S Jain, J Sha, H Batra, N Ananthaswamy… - MBio, 2022 - Am Soc Microbiol
ABSTRACT The US Food and Drug Administration-authorized mRNA-and adenovirus-
based SARS-CoV-2 vaccines are intramuscularly injected in two doses and effective in …

Spinal cord injury changes the structure and functional potential of gut bacterial and viral communities

J Du, AA Zayed, KA Kigerl, K Zane, MB Sullivan… - Msystems, 2021 - Am Soc Microbiol
Emerging data indicate that gut dysbiosis contributes to many human diseases, including
several comorbidities that develop after traumatic spinal cord injury (SCI). To date, all …

Does the microbiome and virome contribute to myalgic encephalomyelitis/chronic fatigue syndrome?

F Newberry, SY Hsieh, T Wileman… - Clinical Science, 2018 - portlandpress.com
Myalgic encephalomyelitis (ME)/chronic fatigue syndrome (CFS)(ME/CFS) is a disabling and
debilitating disease of unknown aetiology. It is a heterogeneous disease characterized by …

Bacteriophage infection and killing of intracellular Mycobacterium abscessus

AA Schmalstig, A Wiggins, D Badillo, KS Wetzel… - Mbio, 2024 - Am Soc Microbiol
Mycobacterium abscessus is a nontuberculous mycobacteria that contributes to the decline
and death of patients with lung diseases such as cystic fibrosis and other muco-obstructive …

Microbiological and ultrastructural evaluation of bacteriophage 191219 against planktonic, intracellular and biofilm infection with Staphylococcus aureus

GK Mannala, M Rupp, N Walter… - … Cells and Materials, 2022 - epub.uni-regensburg.de
Infections of orthopaedic implants, such as fracture fixation devices and total-joint
prostheses, are devastating complications. Staphylococcus aureus (S. aureus) is a …