Dual-specificity tyrosine phosphorylation-regulated kinase 1 A (DYRK1A) is a conserved
protein kinase that plays essential roles in various biological processes. It is located in the …

Dual-specificity tyrosine phosphorylation-regulated kinases (DYRK1A, 1B, 2-4) and cdc2-
like kinases (CLK1-4) belong to the CMGC group of serine/threonine kinases. These protein …

Abstract α-Glucosidase is an important therapeutic target of diabetes mellitus. To find potent
α-glucosidase inhibitors, thirty-one β-carboline derivatives containing piperazine moieties …

Currently, heterocycles have occupied an important position in the fields of drug design.
Among them, azaindole moiety is regarded as one privileged scaffold to develop therapeutic …

Alzheimer's disease (AD) is a chronic and progressive neurodegenerative disease,
characterized by irreversible cognitive impairment, memory loss and behavioral …

Dual-specificity tyrosine phosphorylation-regulated kinase 1A (DYRK1A) is an evolutionarily
conserved protein kinase and the most studied member of the Dual-specificity tyrosine …

Cyclin-dependent kinase 5 (CDK5) protein plays an important role not only in the central
nervous system but also in the periphery, including immune response, regulation of insulin …

Diabetic foot ulcer (DFU), a serious complication of diabetes, remains a clinical challenge.
MicroRNAs affect inflammation and may have therapeutic value in DFU. Here, we find that …

The pathogenesis of diabetes mellitus is characterized by insulin resistance and islet β-cell
dysfunction. Up to now, the focus of diabetes treatment has been to control blood glucose to …

A series of indole-based bisacylhydrazone derivatives 4a∼ 4v were synthesized and
assessed for their α-glucosidase activities. The results presented that all synthesized …