Mitochondrial energetic adaptations encompass a plethora of conserved processes that
maintain cell and organismal fitness and survival in the changing environment by adjusting …

Cells metabolize nutrients for biosynthetic and bioenergetic needs to fuel growth and
proliferation. The uptake of nutrients from the environment and their intracellular metabolism …

Stem cells are characterized by their ability to self-renew and differentiate into many different
cell types. Research has focused primarily on how these processes are regulated at a …

Dysregulation of mRNA translation is a frequent feature of neoplasia. Many oncogenes and
tumour suppressors affect the translation machinery, making aberrant translation a …

Metformin is a drug commonly prescribed to treat patients with type 2 diabetes. Here we
show that long-term treatment with metformin (0.1% w/w in diet) starting at middle age …

Cancer is a major health issue worldwide, and the global burden of cancer is expected to
increase in the coming years. Whereas the limited success with current therapies has driven …

More than 20 years after its discovery, our understanding of target of rapamycin (TOR)
signalling continues to grow. Recent global'omics' studies have revealed physiological roles …

The mechanisms that link environmental and intracellular stimuli to mitochondrial functions,
including fission/fusion, ATP production, metabolite biogenesis, and apoptosis, are not well …

Metformin is the most widely prescribed drug for the treatment of type 2 diabetes. However,
knowledge of the full effects of metformin on biochemical pathways and processes in its …

Translation is a key step in the regulation of gene expression and one of the most energy-
consuming processes in the cell. In response to various stimuli, multiple signaling pathways …