Plants, marine organisms, and microorganisms have evolved complex chemical defense
and signaling systems that are designed to protect them from predators and provide other …

The enediyne antibiotics, the potent anticancer agents that contain diyne-ene functional
groups, are appreciated for their novel molecular architecture, their remarkable biological …

The natural compounds that interfere with cellular DNA such as enediyne antitumor
antibiotics might be important chemotherapeutic agents for the treatment of cancer. In this …

The enediynes are one of the most fascinating families of bacterial natural products given
their unprecedented molecular architecture and extraordinary cytotoxicity. Enediynes are …

Tandem transformations of 1, 3-diynyl propiolate derivatives are described. The Alder-ene
reaction generates an enyne-allene, which undergoes a formal 1, 7-H shift or a Diels–Alder …

A microscale protocol for determination of absolute configurations of 2, 3-epoxy alcohols is
described. 2, 3-Disubstituted (cis and trans), 2, 2-disubstituted, 2, 2, 3-trisubstituted, and 2, 3 …

The last one hundred years have witnessed a dramatic increase in the power and reach of
total synthesis. The pantheon of accomplishments in the field includes the total synthesis of …

Abstract A new [4+ 2] cycloaddition of allenyne‐alkyne is developed. The reaction is
believed to proceed with forming an α, 3‐dehydrotoluene intermediate. This species …

The streamlined assembly of the ansamacrolide framework of the kedarcidin chromophore
via an efficient atropselective Sonogashira coupling step is described. To this end, two …

1.12-biosynthesis of enediyne natural products Page 396 Biological Activity 1.12 Biosynthesis
of Enediyne Natural Products Ajeeth Adhikari and Christiana N Teijaro , The Scripps Research …