In the hippocampus GABAergic local circuit inhibitory interneurons represent only~ 10–15%
of the total neuronal population; however, their remarkable anatomical and physiological …

The endocannabinoid (eCB) system has emerged as a central integrator linking the
perception of external and internal stimuli to distinct neurophysiological and behavioural …

Fragile X syndrome (FXS) results from a genetic mutation in a single gene yet produces a
phenotypically complex disorder with a range of neurological and psychiatric problems …

Endocannabinoids (eCBs) are a family of lipid molecules that act as key regulators of
synaptic transmission and plasticity. They are synthetized “on demand” following …

Fragile X syndrome (FXS), the most-frequently inherited form of intellectual disability and the
most-prevalent single-gene cause of autism, results from a lack of fragile X mental …

The neurotransmitter glutamate facilitates neuronal signalling at excitatory synapses.
Glutamate is released from the presynaptic membrane into the synaptic cleft. Across the …

Autism spectrum disorder (ASD) is comprised of several conditions characterized by
alterations in social interaction, communication, and repetitive behaviors. Genetic and …

The Fragile X Syndrome (FXS) is one of the most common forms of inherited intellectual
disability in all human societies. Caused by the transcriptional silencing of a single gene, the …

Our understanding of fragile X syndrome (FXS) pathophysiology continues to improve and
numerous potential drug targets have been identified. Yet, current prescribing practices are …

The endogenous cannabinoid transmitter system regulates synaptic transmission
throughout the nervous system. Unlike conventional transmitters, specific stimuli induce …