The extracellular matrix is a fundamental, core component of all tissues and organs, and is
essential for the existence of multicellular organisms. From the earliest stages of organism …

The six mammalian glycosaminoglycans (GAGs), chondroitin sulfate, dermatan sulfate,
heparin, heparan sulfate, hyaluronan, and keratan sulfate, are linear polysaccharides …

Proteoglycans (PGs) represent a large proportion of the components that constitute the
extracellular matrix (ECM). They are a diverse group of glycoproteins characterized by a …

Glycosaminoglycans (GAGs) are complex linear polysaccharides, which are covalently
attached to core proteins (except for hyaluronan) to form proteoglycans. They play key roles …

Extracellular matrix (ECM) macromolecules together with a multitude of different molecules
residing in the extracellular space play a vital role in the regulation of cellular phenotype and …

Identifying metabolic steps that are specifically required for the survival of cancer cells but
are dispensable in normal cells remains a challenge. Here we report a therapeutic …

Multidrug resistance (MDR) seriously limits the clinical application of chemotherapy. A
mechanism underlying MDR is the overexpression of efflux transporters associated with …

Circulating tumor cells (CTCs) are accessible by liquid biopsies via an easy blood draw.
They represent not only the primary tumor site, but also potential metastatic lesions, and …

Simple Summary This review takes the extracellular matrix (ECM) as the starting point, and
describes its influence and related mechanisms on the biological behavior of pancreatic …

Simple Summary The extracellular matrix (ECM) has emerged as a critical part of the tumor
microenvironment. This glycoprotein-and proteoglycan-rich part of the tumor serves as a …