New achievements in the synthesis of pyrrolo[1,2-a]quinoxalines

AA Kalinin, LN Islamova, GM Fazleeva - Chemistry of Heterocyclic …, 2019 - Springer
This review article describes methods for the preparation of pyrrolo [1, 2-a] quinoxalines,
covering literature sources from the last 10 years. The attention was largely paid to new …

Use of AlCl 3 in Friedel Crafts arylation type reactions and beyond: an overview on the development of unique methodologies leading to N-heteroarenes

R Sunke, SB Nallapati, JS Kumar, KS Kumar… - Organic & Biomolecular …, 2017 - pubs.rsc.org
As a privileged class of heterocyclic compounds N-heteroarenes have found enormous
applications in many areas including medicinal/pharmaceutical chemistry and drug …

New ferrocenic pyrrolo [1, 2-a] quinoxaline derivatives: Synthesis, and in vitro antimalarial activity–Part II

J Guillon, E Mouray, S Moreau, C Mullié, I Forfar… - European journal of …, 2011 - Elsevier
Following our search for antimalarial compounds, novel series of ferrocenyl-substituted
pyrrolo [1, 2-a] quinoxalines 1-2 were synthesized from ferrocene-carboxaldehyde and …

Synthesis and biological evaluation of novel substituted pyrrolo [1, 2-a] quinoxaline derivatives as inhibitors of the human protein kinase CK2

J Guillon, M Le Borgne, C Rimbault, S Moreau… - European Journal of …, 2013 - Elsevier
Herein we describe the synthesis and properties of substituted phenylaminopyrrolo [1, 2-a]
quinoxaline-carboxylic acid derivatives as a novel class of potent inhibitors of the human …

Design, synthesis and antimalarial activity of novel bis{N-[(pyrrolo[1,2-a]quinoxalin-4-yl)benzyl]-3-aminopropyl}amine derivatives

J Guillon, A Cohen, NM Gueddouda… - Journal of enzyme …, 2017 - Taylor & Francis
Novel series of bis-and tris-pyrrolo [1, 2-a] quinoxaline derivatives 1 were synthesized and
tested for in vitro activity upon the intraerythrocytic stage of W2 and 3D7 Plasmodium …

Direct Synthesis of Pyrrolo[1,2-α]quinoxalines via Iron-Catalyzed Transfer Hydrogenation between 1-(2-Nitrophenyl)pyrroles and Alcohols

S Chun, J Ahn, RR Putta, SB Lee, DC Oh… - The Journal of Organic …, 2020 - ACS Publications
Herein, we describe novel iron-catalyzed transfer hydrogenation between alcohols and 1-(2-
nitrophenyl) pyrroles for the synthesis of pyrrolo [1, 2-α] quinoxalines. The tricarbonyl (η4 …

NCS-promoted thiocyanation and selenocyanation of pyrrolo [1, 2-a] quinoxalines

Z Yang, J He, Y Wei, W Li, P Liu, J Zhao… - Organic & Biomolecular …, 2020 - pubs.rsc.org
An efficient NCS-promoted thiocyanation of pyrrolo [1, 2-a] quinoxalines with NH4SCN or
KSCN is described. A series of diverse 1-thiocyanatopyrrolo [1, 2-a] quinoxalines were …

H8-BINOL Chiral Imidodiphosphoric Acids Catalyzed Enantioselective Synthesis of Dihydroindolo-/-pyrrolo[1,2-a]quinoxalines

YS Fan, YJ Jiang, D An, D Sha, JC Antilla… - Organic letters, 2014 - ACS Publications
The first enantioselective synthesis of 5, 6-dihydroindolo [1, 2-a] quinoxalines is achieved by
using a newly developed H8-BINOL-type imidodiphosphoric acid catalyst with low catalyst …

Synthesis of 4-Aryl Pyrrolo[1,2-α]quinoxalines via Iron-Catalyzed Oxidative Coupling from an Unactivated Methyl Arene

J Ahn, SB Lee, I Song, S Chun, DC Oh… - The Journal of Organic …, 2021 - ACS Publications
Herein, we describe the direct synthesis of pyrrolo [1, 2-α] quinoxaline via oxidative coupling
between methyl arene and 1-(2-aminophenyl) pyrroles. Oxidation of the benzylic carbon of …

Identification of Breast Cancer Inhibitors Specific for G Protein‐Coupled Estrogen Receptor (GPER)‐Expressing Cells

F Aiello, G Carullo, F Giordano, E Spina… - …, 2017 - Wiley Online Library
Together with estrogen receptors ERα and ERβ, the G protein‐coupled estrogen receptor
(GPER) mediates important pathophysiological signaling pathways induced by estrogens …