Innate and intrinsic antiviral immunity in Drosophila
A Mussabekova, L Daeffler, JL Imler - Cellular and Molecular Life Sciences, 2017 - Springer
The fruit fly Drosophila melanogaster has been a valuable model to investigate the genetic
mechanisms of innate immunity. Initially focused on the resistance to bacteria and fungi …
mechanisms of innate immunity. Initially focused on the resistance to bacteria and fungi …
Sensing microbial infections in the Drosophila melanogaster genetic model organism
S Liegeois, D Ferrandon - Immunogenetics, 2022 - Springer
Insects occupy a central position in the biosphere. They are able to resist infections even
though they lack an adaptive immune system. Drosophila melanogaster has been used as a …
though they lack an adaptive immune system. Drosophila melanogaster has been used as a …
Death following traumatic brain injury in Drosophila is associated with intestinal barrier dysfunction
RJ Katzenberger, S Chtarbanova, SA Rimkus… - Elife, 2015 - elifesciences.org
Traumatic brain injury (TBI) is a major cause of death and disability worldwide. Unfavorable
TBI outcomes result from primary mechanical injuries to the brain and ensuing secondary …
TBI outcomes result from primary mechanical injuries to the brain and ensuing secondary …
Eya3 partners with PP2A to induce c-Myc stabilization and tumor progression
Eya genes encode a unique family of multifunctional proteins that serve as transcriptional co-
activators and as haloacid dehalogenase-family Tyr phosphatases. Intriguingly, the N …
activators and as haloacid dehalogenase-family Tyr phosphatases. Intriguingly, the N …
EYA4 is inactivated biallelically at a high frequency in sporadic lung cancer and is associated with familial lung cancer risk
In an effort to identify novel biallelically inactivated tumor suppressor genes (TSGs) in
sporadic invasive and preinvasive non-small-cell lung cancer (NSCLC) genomes, we …
sporadic invasive and preinvasive non-small-cell lung cancer (NSCLC) genomes, we …
EYA4 Acts as a New Tumor Suppressor Gene in Colorectal Cancer
A previous genome‐wide methylation array for colorectal cancer (CRC) identified aberrant
promoter methylation of eyes absent 4 (EYA4). However, the correlations between EYA4 …
promoter methylation of eyes absent 4 (EYA4). However, the correlations between EYA4 …
Sterile Inflammation in Drosophila
The study of immune responses in Drosophila has already yielded significant results with
impacts on our understanding of vertebrate immunity, such as the characterization of the Toll …
impacts on our understanding of vertebrate immunity, such as the characterization of the Toll …
Suppression of intestinal dysfunction in a Drosophila model of Parkinson's disease is neuroprotective
The innate immune response mounts a defense against foreign invaders and declines with
age. An inappropriate induction of this response can cause diseases. Previous studies …
age. An inappropriate induction of this response can cause diseases. Previous studies …
Eya3 promotes breast tumor–associated immune suppression via threonine phosphatase–mediated PD-L1 upregulation
Eya proteins are critical developmental regulators that are highly expressed in
embryogenesis but downregulated after development. Amplification and/or re-expression of …
embryogenesis but downregulated after development. Amplification and/or re-expression of …
The Eya phosphatase: Its unique role in cancer
The Eya proteins were originally identified as essential transcriptional co-activators of the
Six family of homeoproteins. Subsequently, the highly conserved C-terminal domains of the …
Six family of homeoproteins. Subsequently, the highly conserved C-terminal domains of the …