Heat shock proteins in oxidative stress and ischemia/reperfusion injury and benefits from physical exercises: a review to the current knowledge

J Szyller, I Bil-Lula - Oxidative Medicine and Cellular Longevity, 2021 - Wiley Online Library
Heat shock proteins (HSPs) are molecular chaperones produced in response to oxidative
stress (OS). These proteins are involved in the folding of newly synthesized proteins and …

Damage-associated molecular patterns in myocardial infarction and heart transplantation: the road to translational success

MJM Silvis, SE Kaffka genaamd Dengler… - Frontiers in …, 2020 - frontiersin.org
In the setting of myocardial infarction (MI), ischemia reperfusion injury (IRI) occurs due to
occlusion (ischemia) and subsequent re-establishment of blood flow (reperfusion) of a …

The role of heat shock proteins and co-chaperones in heart failure

MJ Ranek, MJ Stachowski… - … Transactions of the …, 2018 - royalsocietypublishing.org
The ongoing contractile and metabolic demands of the heart require a tight control over
protein quality control, including the maintenance of protein folding, turnover and synthesis …

Promoting effect of baicalin on nitric oxide production in CMECs via activating the PI3K-AKT-eNOS pathway attenuates myocardial ischemia–reperfusion injury

J Bai, Q Wang, J Qi, H Yu, C Wang, X Wang, Y Ren… - Phytomedicine, 2019 - Elsevier
Objective Baicalin, which is isolated from Scutellariae Radix, has been shown to possess
therapeutic potential for different diseases. Cardiac microvessel injury in myocardial …

Heat shock protein 70: A promising therapeutic target for myocardial ischemia–reperfusion injury

YJ Song, CB Zhong, XB Wang - Journal of cellular physiology, 2019 - Wiley Online Library
Acute myocardial infarction is a major cause of death worldwide. The most important therapy
for limiting ischemic injury and infarct size is timely and efficient myocardial reperfusion …

Heat shock proteins as modulators and therapeutic targets of chronic disease: an integrated perspective

AL Edkins, JT Price, AG Pockley… - … Transactions of the …, 2018 - royalsocietypublishing.org
Many heat shock proteins (HSPs) are essential to survival as a consequence of their role as
molecular chaperones, and play a critical role in maintaining cellular proteostasis by …

Chaperone duality: the role of extracellular and intracellular HSP70 as a biomarker of endothelial dysfunction in the development of atherosclerosis

LC Costa-Beber, GE Hirsch, TG Heck… - Archives of Physiology …, 2022 - Taylor & Francis
The 70-kDa heat shock proteins (HSP70) may provide relevant information about the
endothelial dysfunction in cardiovascular diseases. Located in the intracellular milieu …

Matrine protects cardiomyocytes from ischemia/reperfusion injury by regulating HSP70 expression via activation of the JAK2/STAT3 pathway

S Guo, C Gao, W Xiao, J Zhang, Y Qu, J Li, F Ye - Shock, 2018 - journals.lww.com
Studies have shown that matrine showed cardiovascular protective effects; however, its role
and mechanism in myocardial ischemia/reperfusion (I/R) injury remain unknown. The Janus …

Hsp70 suppresses mitochondrial reactive oxygen species and preserves pulmonary microvascular barrier integrity following exposure to bacterial toxins

X Li, Y Yu, B Gorshkov, S Haigh, Z Bordan… - Frontiers in …, 2018 - frontiersin.org
Pneumonia is a leading cause of death in children and the elderly worldwide, accounting for
15% of all deaths of children under 5 years old. Streptococcus pneumoniae is a common …

Postoperative complications associated with coronary artery bypass graft surgery and their therapeutic interventions

A Pooria, A Pourya, A Gheini - Future Cardiology, 2020 - Taylor & Francis
Coronary artery disease is one of the commonest surgery demanding cardiovascular
diseases. Coronary artery bypass graft surgery is practiced all over the world for the …