Regulation of gene expression plays a central role in adaptive divergence and evolution.
Although the role of gene regulation in microevolutionary processes is gaining wide …

Embryonic myogenesis is a temporally and spatially regulated process that generates
skeletal muscle of the trunk and limbs. During this process, mononucleated myoblasts …

Background Skeletal muscle contributes to roughly 40% of lean body mass, and its loss
contributes to morbidity and mortality in a variety of pathogenic conditions. Significant …

The functional role of Pax7-expressing satellite cells (SCs) in postnatal skeletal muscle
development beyond weaning remains obscure. Therefore, the relevance of SCs during …

Background Skeletal muscles express a highly specialized proteome that allows the
metabolism of energy sources to mediate myofiber contraction. This muscle-specific …

Biological processes are dynamically regulated by signaling networks composed of protein
kinases and phosphatases. Calcineurin, or PP3, is a conserved phosphoserine …

Myotonic dystrophy type 1 (DM1) is a CTG microsatellite expansion (CTGexp) disorder
caused by expression of CUGexp RNAs. These mutant RNAs alter the activities of RNA …

Alternative RNA splicing is a key step in gene expression that allows generation of
numerous messenger RNA transcripts encoding proteins of varied functions from the same …

Background Mutations in the titin gene (TTN) cause a large spectrum of diseases affecting
skeletal and/or cardiac muscle. TTN includes 363 coding exons, a repeated region with a …

Muscles organise pseudo-crystalline arrays of actin, myosin and titin filaments to build force-
producing sarcomeres. To study sarcomerogenesis, we have generated a transcriptomics …