Recognition of arboviruses by the mosquito immune system

BC Prince, E Walsh, TZB Torres, C Rückert - Biomolecules, 2023 - mdpi.com
Arthropod-borne viruses (arboviruses) pose a significant threat to both human and animal
health worldwide. These viruses are transmitted through the bites of mosquitoes, ticks …

An evolutionary perspective to innate antiviral immunity in animals

JT Marques, C Meignin, JL Imler - Cell Reports, 2024 - cell.com
Viruses pose a significant threat to cellular organisms. Innate antiviral immunity
encompasses both RNA-and protein-based mechanisms designed to sense and respond to …

Mechanisms and therapeutic prospect of the JAK-STAT signaling pathway in liver cancer

JJ Jia, X Zhou, Q Chu - Molecular and Cellular Biochemistry, 2024 - Springer
Liver cancer (LC) poses a significant global health challenge due to its high incidence and
poor prognosis. Current systemic treatment options, such as surgery, chemotherapy …

Identification of immune-responsive circular RNAs in shrimp (Litopenaeus vannamei) upon yellow head virus infection

A Massu, K Mahanil, S Limkul, T Phiwthong… - Fish & Shellfish …, 2024 - Elsevier
Circular RNAs (circRNAs) are a subclass of non-coding RNAs (ncRNAs) formed through a
process known as back-splicing. They play a crucial role in the genetic regulation of various …

The non-receptor protein tyrosine phosphatase PTPN6 mediates a positive regulatory approach from the interferon regulatory factor to the JAK/STAT pathway in …

M Luo, X Xu, X Liu, W Shen, L Yang, Z Zhu… - Frontiers in …, 2022 - frontiersin.org
SH2-domain-containing protein tyrosine phosphatases (PTPs), belonging to the class I PTP
superfamily, are responsible for the dephosphorylation on the phosphorylated tyrosine …

cGAS-like receptor-mediated immunity: the insect perspective

H Cai, C Meignin, JL Imler - Current opinion in immunology, 2022 - Elsevier
Highlights•Induction of antiviral genes contributes to defense against viruses in
insects.•STING triggers NF-κB-dependent gene expression to fight infection in insects.•A …

Metabolomic Investigation of Ultraviolet Ray-Inactivated White Spot Syndrome Virus-Induced Trained Immunity in Marsupenaeus japonicus

S Zang, LX Lv, CF Liu, P Zhang, C Li… - Frontiers in …, 2022 - frontiersin.org
Trained immunity is driven by metabolism and epigenetics in innate immune cells in
mammals. The phenomenon of trained immunity has been identified in invertebrates …

Effects of PmDOME and PmSTAT knockdown on white spot syndrome virus infection in Penaeus monodon

P Laohawutthichai, T Jatuyosporn, P Supungul… - Scientific Reports, 2023 - nature.com
Janus kinase/signal transducers and activators of transcription (JAK/STAT) signaling
pathway plays an important role in antiviral immunity. This research reports the full-length …

Integrinβ1/FAK/ERK signalling pathway is essential for Chinese mitten crab Eriocheir sinensis hemocyte survival

Y Zhao, X Zhang, X Zhang, G Shen, W Li… - Fish & Shellfish …, 2023 - Elsevier
Integrins are cellular adhesion molecules that mediate cell-cell, cell-extracellular matrix, and
cell-pathogen interactions. Integrins can stimulate various signaling pathways by binding to …

Heterologous expression of the insect SVWC peptide WHIS1 inhibits Candida albicans invasion into A549 and HeLa epithelial cells

M Chen, WK Huang, Y Yao, SM Wu, YX Yang… - Frontiers in …, 2024 - frontiersin.org
Candida albicans (C. albicans), a microbe commonly isolated from Candida vaginitis
patients with vaginal tract infections, transforms from yeast to hyphae and produces many …