Extensive studies have shown how bilateral symmetry of the vertebrate embryo is broken
during early development, resulting in a molecular left-right bias in the mesoderm. However …

The vertebrate heart tube forms from epithelial progenitor cells in the early embryo and
subsequently elongates by progressive addition of second heart field (SHF) progenitor cells …

Cardiac interstitium is a complex and dynamic environment, vital for normal cardiac structure
and function. Telocytes are active cellular players in regulating main events that feature …

Abstract Background Canonical Wnt signaling is involved in a variety of biological processes
including stem cell renewal and differentiation, embryonic development, and tissue …

The second heart field (SHF) harbors progenitors that are important for heart formation, but
little is known about its morphogenesis. We show that SHF population in the mouse …

Failure to form the septal structures that separate the left and right cardiac chambers results
in defects that allow shunting of blood from one side of the heart to the other, leading to the …

The mammalian heart is the first organ to form and is critical for embryonic survival and
development. With an occurrence of 1%, congenital heart defects (CHDs) are also the most …

The phenotypic spectrum of congenital heart defects (CHDs) is contributed by both genetic
and environmental factors. Their interactions are profoundly heterogeneous but may operate …

Wnt11 regulates early cardiac development and left ventricular compaction in the heart, but
it is not known how Wnt11 regulates postnatal cardiac maturation and response to cardiac …

To adequately connect zebrafish medical models to human biology, it is essential that gene
nomenclature reflects gene orthology. Analysis of gene phylogenies and conserved …