The history of hepatitis C virus (HCV): Basic research reveals unique features in phylogeny, evolution and the viral life cycle with new perspectives for epidemic control

J Bukh - Journal of hepatology, 2016 - Elsevier
The discovery of hepatitis C virus (HCV) in 1989 permitted basic research to unravel critical
components of a complex life cycle for this important human pathogen. HCV is a highly …

[PDF][PDF] Consensus proposals for a unified system of nomenclature of hepatitis C virus genotypes

P Simmonds, J Bukh, C Combet, G Deléage… - …, 2005 - Wiley Online Library
International standardization and coordination of the nomenclature of variants of hepatitis C
virus (HCV) is increasingly needed as more is discovered about the scale of HCV‐related …

Efficient replication of the genotype 2a hepatitis C virus subgenomic replicon

T Kato, T Date, M Miyamoto, A Furusaka, K Tokushige… - Gastroenterology, 2003 - Elsevier
Background & Aims: Although the hepatitis C virus (HCV) subgenomic replicon system has
been widely used in the study of HCV, this system is available only for a few related …

New hepatitis C virus (HCV) genotyping system that allows for identification of HCV genotypes 1a, 1b, 2a, 2b, 3a, 3b, 4, 5a, and 6a

O Ohno, M Mizokami, RR Wu, MG Saleh… - Journal of clinical …, 1997 - Am Soc Microbiol
Recent studies have focused on whether different hepatitis C virus (HCV) genotypes are
associated with different profiles of pathogenicity, infectivity, and response to antiviral …

[HTML][HTML] Intramembrane proteolysis promotes trafficking of hepatitis C virus core protein to lipid droplets

J McLauchlan, MK Lemberg, G Hope… - The EMBO journal, 2002 - embopress.org
Hepatitis C virus (HCV) is the major causative pathogen associated with liver cirrhosis and
hepatocellular carcinoma. The virus has a positive‐sense RNA genome encoding a single …

Classification, nomenclature, and database development for hepatitis C virus (HCV) and related viruses: proposals for standardization

B Robertson, G Myers, C Howard, T Brettin, J Bukh… - Archives of …, 1998 - Springer
This paper presents a summary of the recommendations that were formulated for the
purposes of unifying the nomenclature for hepatitis C virus (HCV), based upon guidelines of …

Genetic epidemiology of hepatitis C virus throughout Egypt

SC Ray, RR Arthur, A Carella, J Bukh… - The Journal of …, 2000 - academic.oup.com
Hepatitis C virus (HCV) infection is a major health problem in Egypt, where the
seroprevalence is 10–20-fold higher than that in the United States. To characterize the HCV …

An overview of HCV molecular biology, replication and immune responses

UA Ashfaq, T Javed, S Rehman, Z Nawaz, S Riazuddin - Virology journal, 2011 - Springer
Hepatitis C virus (HCV) causes acute and chronic hepatitis which can eventually lead to
permanent liver damage, hepatocellular carcinoma and death. Currently, there is no vaccine …

Hepatitis C: an epidemiological review

MI Memon, MA Memon - Journal of viral hepatitis, 2002 - Wiley Online Library
The aim of the study was to analyse the current literature regarding the mode of transmission
of HCV and its global prevalence in different groups of people. A systematic review of the …

Properties of the hepatitis C virus core protein: a structural protein that modulates cellular processes

McLauchlan - Journal of viral hepatitis, 2000 - Wiley Online Library
The core protein of hepatitis C virus (HCV) is believed to form the capsid shell of virus
particles. Maturation of the protein is achieved through cleavage by host cell proteases to …