Citrus fruits as a treasure trove of active natural metabolites that potentially provide benefits for human health

X Lv, S Zhao, Z Ning, H Zeng, Y Shu, O Tao… - Chemistry Central …, 2015 - Springer
Citrus fruits, which are cultivated worldwide, have been recognized as some of the most high-
consumption fruits in terms of energy, nutrients and health supplements. What is more, a …

A review of the pharmacological and therapeutic effects of auraptene

B Bibak, F Shakeri, GE Barreto, Z Keshavarzi… - Biofactors, 2019 - Wiley Online Library
There is a growing awareness in herbal medications as they are usually safe and devoid of
significant adverse effects. Auraptene is a natural bioactive monoterpene coumarin ether …

Proinflammatory cytokine interleukin-1β suppresses cold-induced thermogenesis in adipocytes

T Goto, S Naknukool, R Yoshitake, Y Hanafusa… - Cytokine, 2016 - Elsevier
In this study, we investigated the effects of interleukin-1β (IL-1β), a typical proinflammatory
cytokine on the β-adrenoreceptor-stimulated induction of uncoupling protein 1 (UCP1) …

Auraptene exerts protective effects on maternal separation stress-induced changes in behavior, hippocampus, heart and serum of mice

M Arabi, SH Nasab, Z Lorigooini, SN Boroujeni… - International …, 2021 - Elsevier
Early life stress is associated with various complications. Auraptene has significant
antioxidant and anti-inflammatory effects. This study aimed to assess the probable …

Anti-inflammatory effects of 6-methylcoumarin in LPS-stimulated RAW 264.7 macrophages via regulation of MAPK and NF-κB signaling pathways

JK Kang, YC Chung, CG Hyun - Molecules, 2021 - mdpi.com
Persistent inflammatory reactions promote mucosal damage and cause dysfunction, such as
pain, swelling, seizures, and fever. Therefore, in this study, in order to explore the anti …

Anti-inflammatory natural prenylated phenolic compounds-potential lead substances

V Brezani, K Smejkal, J Hosek… - Current Medicinal …, 2018 - ingentaconnect.com
Background: Natural phenolics are secondary plant metabolites, which can be divided into
several categories with the common structural feature of phenolic hydroxyl. The biological …

The antioxidant auraptene improves aged oocyte quality and embryo development in mice

YH Kim, SY Lee, EY Kim, KH Kim, MK Koong, KA Lee - Antioxidants, 2022 - mdpi.com
Decrease in quality of postovulatory aged oocytes occurs due to oxidative stress and leads
to low fertilization and development competence. It is one of the main causes that exerting …

Auraptene regulates Th1/Th2/TReg balances, NF-κB nuclear localization and nitric oxide production in normal and Th2 provoked situations in human isolated …

VR Askari, VB Rahimi, SA Rezaee, MH Boskabady - Phytomedicine, 2018 - Elsevier
Background Auraptene as member of dietary coumarins, is found in citrus fruits. Former
studies have demonstrated its anti-inflammatory and anti-cancer activity. Purpose The …

Inonotus sanghuang Polyphenols Attenuate Inflammatory Response Via Modulating the Crosstalk Between Macrophages and Adipocytes

M Zhang, Y Xie, X Su, K Liu, Y Zhang, W Pang… - Frontiers in …, 2019 - frontiersin.org
Aims: Obesity is characterized as a chronic state of low-grade inflammation with progressive
immune cell infiltration into adipose tissue. Adipose tissue macrophages play a critical role …

Synthesized enone fatty acids resembling metabolites from gut microbiota suppress macrophage‐mediated inflammation in adipocytes

HE Yang, Y Li, A Nishimura, HF Jheng… - Molecular nutrition & …, 2017 - Wiley Online Library
Scope Recent reports indicate that gut microbiota and their metabolites may regulate host
inflammatory conditions, including the chronic inflammation of obese adipose tissues. In this …