Epidemiological and experimental data demonstrate a strong correlation between age-
related chronic inflammation (inflamm-aging) and cancer development. However, a …

The aging process starts directly after birth and lasts for the entire lifespan; it manifests itself
with a decline in an organism's ability to adapt and is linked to the development of age …

Hallmarks of cancer and hallmarks of aging - PMC Back to Top Skip to main content NIH
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Over the last 50 years, major improvements have been made in our understanding of the
driving forces, both parallel and opposing, that lead to aging and cancer. Many theories on …

Aging is the phenotype resulting from accumulation of genetic, cellular, and molecular
damages. Many factors have been identified as either the cause or consequence of age …

Making headlines, a thought-provocative paper by Neff, Ehninger and coworkers claims that
rapamycin extends life span but has limited effects on aging. How is that possibly possible …

The transcription factors NF-κB and p53 as well as their crosstalk determine the fate of tumor
cells upon therapeutic interventions. Replicative stress and cytokines promote signaling …

Cancer is a disease of aging as older adults are much more likely to develop cancer
compared with their younger counterparts. In the United States, approximately 60% of all …

Vascular calcifications are frequent in chronic renal disease and are associated to
significant cardiovascular morbidity and mortality. The long term predictive value of coronary …

The inhibitor of apoptosis protein XIAP (X-linked inhibitor of apoptosis protein) is a well-
documented protein that is located in cytoplasm acting as a potent regulator of cell …