[HTML][HTML] Small molecule-based immunomodulators for cancer therapy
Y Wu, Z Yang, K Cheng, H Bi, J Chen - Acta Pharmaceutica Sinica B, 2022 - Elsevier
Immunotherapy has led to a paradigm shift in the treatment of cancer. Current cancer
immunotherapies are mostly antibody-based, thus possessing advantages in regard to …
immunotherapies are mostly antibody-based, thus possessing advantages in regard to …
RORγt agonist enhances anti-PD-1 therapy by promoting monocyte-derived dendritic cells through CXCL10 in cancers
L Xia, E Tian, M Yu, C Liu, L Shen, Y Huang… - Journal of Experimental …, 2022 - Springer
Background The overall response rate to checkpoint blockade remains unsatisfactory,
partially due to the immune-suppressive tumor microenvironment. A retinoic acid-related …
partially due to the immune-suppressive tumor microenvironment. A retinoic acid-related …
La-Catalyzed Decarbonylation of Formamides and Its Applications
S Li, T Rajeshkumar, J Liu, L Maron, X Zhou - Organic Letters, 2022 - ACS Publications
Herein we report the first catalytic decarbonylation and decarbonylative hydroamination of
formamides without using additives enabled by a redox-neutral rare earth catalyst. The …
formamides without using additives enabled by a redox-neutral rare earth catalyst. The …
Discovery of Biaryl Amide Derivatives as Potent, Selective, and Orally Bioavailable RORγt Agonists for Cancer Immunotherapy
L Lu, Y Huang, M Song, N Sun, L Xia… - Journal of Medicinal …, 2023 - ACS Publications
The master transcription factor receptor retinoic acid receptor-related orphan receptor γt
(RORγt) regulates the differentiation of T-helper 17 (Th17) cells and the production of …
(RORγt) regulates the differentiation of T-helper 17 (Th17) cells and the production of …
Celastrol attenuates Guillain-Barré syndrome by inhibiting TLR4/NF-ΚB/STAT3 pathway-mediated Th1/Th17 cell differentiation.
H Shao, W Fan, Y Tang - General Physiology & Biophysics, 2023 - search.ebscohost.com
Guillain-Barré syndrome (GBS) is an acute immune-mediated paralytic neuropathy with
variable disease course and outcome. In this study, we aimed to investigate the therapeutic …
variable disease course and outcome. In this study, we aimed to investigate the therapeutic …
MicroRNA-99b Regulates Bacillus Calmette-Guerin-Infected Immature Dendritic Cell-Induced CD4+ T Cell Differentiation by Targeting mTOR Signaling
L Zhen, Y Chen, J Gao, B Li… - Critical Reviews™ in …, 2024 - dl.begellhouse.com
This study aimed to elucidate the mechanisms by which microRNA-99b (miR-99b) regulates
CD4+ T cell differentiation induced by Bacillus Calmette-Guerin (BCG)-infected immature …
CD4+ T cell differentiation induced by Bacillus Calmette-Guerin (BCG)-infected immature …