Exosome processing and characterization approaches for research and technology development

JJ Lai, ZL Chau, SY Chen, JJ Hill… - Advanced …, 2022 - Wiley Online Library
Exosomes are extracellular vesicles that share components of their parent cells and are
attractive in biotechnology and biomedical research as potential disease biomarkers as well …

Exosomes: key players in cancer and potential therapeutic strategy

J Dai, Y Su, S Zhong, L Cong, B Liu, J Yang… - Signal transduction and …, 2020 - nature.com
Exosomes are extracellular vesicles secreted by most eukaryotic cells and participate in
intercellular communication. The components of exosomes, including proteins, DNA, mRNA …

Exosome-based smart drug delivery tool for cancer theranostics

R Kar, R Dhar, S Mukherjee, S Nag… - ACS biomaterials …, 2023 - ACS Publications
Exosomes are the phospholipid-membrane-bound subpopulation of extracellular vesicles
derived from the plasma membrane. The main activity of exosomes is cellular …

Tumor microenvironment complexity and therapeutic implications at a glance

R Baghban, L Roshangar… - Cell Communication and …, 2020 - Springer
The dynamic interactions of cancer cells with their microenvironment consisting of stromal
cells (cellular part) and extracellular matrix (ECM) components (non-cellular) is essential to …

The role of macrophage subtypes and exosomes in immunomodulation

AT Gharavi, NA Hanjani, E Movahed… - Cellular & molecular …, 2022 - Springer
Macrophages are influential members of the innate immune system that can be reversibly
polarized by different microenvironment signals. Cell polarization leads to a wide range of …

Using single-vesicle technologies to unravel the heterogeneity of extracellular vesicles

G Bordanaba-Florit, F Royo, SG Kruglik… - Nature …, 2021 - nature.com
Extracellular vesicles (EVs) are heterogeneous lipid containers with a complex molecular
cargo comprising several populations with unique roles in biological processes. These …

Emerging prospects of exosomes for cancer treatment: from conventional therapy to immunotherapy

GH Nam, Y Choi, GB Kim, S Kim, SA Kim… - Advanced …, 2020 - Wiley Online Library
Exosomes are a class of extracellular vesicles of around 100 nm in diameter that are
secreted by most cells and contain various bioactive molecules reflecting their cellular origin …

Designer exosomes: a new platform for biotechnology therapeutics

D Jafari, S Shajari, R Jafari, N Mardi, H Gomari, F Ganji… - BioDrugs, 2020 - Springer
Desirable features of exosomes have made them a suitable manipulative platform for
biomedical applications, including targeted drug delivery, gene therapy, cancer diagnosis …

The role of Exosomal miRNAs in cancer

C Li, T Zhou, J Chen, R Li, H Chen, S Luo… - Journal of translational …, 2022 - Springer
Exosomal miRNAs have attracted much attention due to their critical role in regulating genes
and the altered expression of miRNAs in virtually all cancers affecting humans (Sun et al. in …

Long non-coding RNA mediated drug resistance in breast cancer

D Singh, YG Assaraf, RN Gacche - Drug Resistance Updates, 2022 - Elsevier
Breast cancer is one of the most prevalent cancers in women and a leading cause of
mortality. As per the GLOBCAN report of 2021, breast cancer has surpassed lung cancer …