Adipose tissue (AT) is a highly heterogeneous organ. Beside the heterogeneity associated
to different tissue types (white, brown, and 'brite') and its location-related heterogeneity …

Quantifying the differential expression of genes in various human organs, tissues, and cell
types is vital to understand human physiology and disease. Recently, several large‐scale …

The gut microbiota has been proposed as an environmental factor that promotes the
progression of metabolic diseases. Here, we investigated how the gut microbiota modulates …

To elucidate the molecular mechanisms underlying non‐alcoholic fatty liver disease
(NAFLD), we recruited 86 subjects with varying degrees of hepatic steatosis (HS). We …

To investigate the biological processes that are altered in obese subjects, we generated cell-
specific integrated networks (INs) by merging genome-scale metabolic, transcriptional …

Hepatocellular carcinoma (HCC) is a deadly form of liver cancer that is increasingly
prevalent. We analyzed global gene expression profiling of 361 HCC tumors and 49 …

Objective Plasma levels of branched-chain amino acids (BCAA) are consistently elevated in
obesity and type 2 diabetes (T2D) and can also prospectively predict T2D. However, the role …

(1) Adipsin is an adipokine that may link increased fat mass and adipose tissue dysfunction
to obesity-related cardiometabolic diseases. Here, we investigated whether adipsin serum …

Objectives Obesity in humans and mice is associated with elevated levels of two hormones
responsive to cellular stress, namely GDF15 and FGF21. Over-expression of each of these is …

Background/Aims: Altered expression and circulating levels of glutathione peroxidase 3
(GPX3) have been observed in obesity and type 2 diabetes (T2D) across species. Here, we …