Two new pathways, T cell receptor signaling and a hematopoietic-specific signal
transduction pathway, have been discovered that allow future pharmacologic interventions …

Rheumatoid arthritis is a chronic inflammatory autoimmune disease of unknown cause. The
immune response against citrullinated Ags has recently become the prime suspect for …

Protein arginine deiminase 4 (PAD4) is a Ca2+-dependent enzyme that catalyzes the
posttranslational conversion of arginine to citrulline (Arg→ Cit) in a number of proteins …

Abstract Peptidylarginine deiminase type 4 (PADI4) genotypes were shown to influence
susceptibility to rheumatoid arthritis (RA) in the Japanese population. Such an association …

Objectives. Strong genetic association of rheumatoid arthritis (RA) with PADI4 (peptidyl
arginine deiminase) has previously been described in Japanese, although this was not …

Citrullination, a posttranslational modification of peptidyl arginine to citrulline, plays an
essential role in rheumatoid arthritis (RA). Citrullination is catalyzed by a group of …

Human peptidylarginine deiminase type IV (PAD4), a Ca2+-dependent enzyme known to
convert arginine residues to citrulline residues in histones, has been shown to be associated …

Introduction: The protein-arginine deiminase (PAD) 4 enzyme plays an important role in the
pathogenesis of rheumatoid arthritis (RA) and also represents an antigenic target. Anti …

Background: Recent evidence suggests that distinction of subsets of rheumatoid arthritis
(RA) depending on anti-cyclic citrullinated peptide antibody (anti-CCP) status may be helpful …

Background: A functional haplotype of the peptidylarginine deiminase 4 (PADI4) gene has
recently been identified as a rheumatoid arthritis susceptibility gene in a Japanese but not in …