Combining sensors and actuators with electrowetting-on-dielectric (EWOD): advanced digital microfluidic systems for biomedical applications

Z Tong, C Shen, Q Li, H Yin, H Mao - Analyst, 2023 - pubs.rsc.org
The concept of digital microfluidics (DMF) enables highly flexible and precise droplet
manipulation at a picoliter scale, making DMF a promising approach to realize integrated …

Unlocking the potential of microfluidics in mass spectrometry-based immunopeptidomics for tumor antigen discovery

C Stutzmann, J Peng, Z Wu, C Savoie, I Sirois… - Cell Reports …, 2023 - cell.com
The identification of tumor-specific antigens (TSAs) is critical for developing effective cancer
immunotherapies. Mass spectrometry (MS)-based immunopeptidomics has emerged as a …

Noncontact charge shielding knife for liquid microfluidics

X Han, S Tan, R Jin, L Jiang… - Journal of the American …, 2023 - ACS Publications
Multibehavioral droplet manipulation in a precise and programmed manner is crucial for
stoichiometry, biological virus detection, and intelligent lab-on-a-chip. Apart from …

All-in-One digital microfluidics pipeline for proteomic sample preparation and analysis

J Peng, C Chan, S Zhang, AA Sklavounos… - Chemical …, 2023 - pubs.rsc.org
Highly sensitive and reproducible analysis of samples containing low amounts of protein is
restricted by sample loss and the introduction of contaminants during processing. Here, we …

Integrated Microsystem Toward High‐Throughput Automated Green Synthesis and Raman Enhancement Performance Screening of Noble‐Metal@ Cu‐MOF

C Fan, Y Luo, M Tian, M Zhou, L Wang… - Advanced Functional …, 2023 - Wiley Online Library
Abstract “Green Synthesis” has been broadly applied in drug synthesis and nanomaterial
preparation. The integration of automated micro‐synthesis and high‐throughput screening …

Noncontact Microfluidics of Highly Viscous Liquids for Accurate Self‐Splitting and Pipetting

X Han, S Tan, Q Wang, X Zuo, L Heng… - Advanced …, 2024 - Wiley Online Library
Accurate dosing for various liquids, especially for highly viscous liquids, is fundamental in
wide‐ranging from molecular crosslinking to material processing. Despite droppers or …

A monolithic microfluidic probe for ambient mass spectrometry imaging of biological tissues

LX Jiang, M Polack, X Li, M Yang, D Belder, J Laskin - Lab on a Chip, 2023 - pubs.rsc.org
Ambient mass spectrometry imaging (MSI) is a powerful technique that allows for the
simultaneous mapping of hundreds of molecules in biological samples under atmospheric …

Digital Microfluidics for Sample Preparation in Low‐Input Proteomics

MK Steinbach, J Leipert, T Matzanke… - Small Methods, 2024 - Wiley Online Library
Low‐input proteomics, also referred to as micro‐or nanoproteomics, has become
increasingly popular as it allows one to elucidate molecular processes in rare biological …

Toward nanofluidics‐based mass spectrometry for exploring the unknown complex and heterogeneous subcellular worlds

N Chantipmanee, Y Xu - View, 2023 - Wiley Online Library
Exploring unknown matter in an ultrasmall volume object, such as unknown subcellular
matter in a single cell, requires an analytical technique that identifies unknown matter in …

A syndromic diagnostic assay on a macrochannel-to-digital microfluidic platform for automatic identification of multiple respiratory pathogens

C Dong, F Li, Y Sun, D Long, C Chen, M Li, T Wei… - Lab on a Chip, 2024 - pubs.rsc.org
The worldwide COVID-19 pandemic has changed people's lives and the diagnostic
landscape. The nucleic acid amplification test (NAT) as the gold standard for SARS-CoV-2 …