Objective Use of the frailty index to measure an accumulation of deficits has been proven a
valuable method for identifying elderly people at risk for increased vulnerability, disease …

Irisin is a myokine that leads to increased energy expenditure by stimulating the'browning'of
white adipose tissue. In the first description of this hormone, increased levels of circulating …

Introduction Irisin is a myokine/adipokine induced by the exercise in mice and humans,
which is proposed to induce “browning” of white adipose tissue, its primary target, thus …

Homeostasis of energy is regulated by genetic factors, food intake, and energy expenditure.
When energy input is greater than expenditure, the balance is positive, which can lead to …

Obesity and type II diabetes are characterized by insulin resistance in peripheral tissues. A
high caloric intake combined with a sedentary lifestyle is the leading cause of these …

Rationale: The newly discovered myokine irisin has been proposed to affect obesity and
metabolism by promoting browning of white adipose tissue. However, clinical and functional …

FNDC5/irisin has been recently postulated as beneficial in the treatment of obesity and
diabetes because it is induced in muscle by exercise, increasing energy expenditure …

Purpose An imbalance in the production of adipokines and myokines impairs the energy
expenditure, increases adipocyte and develops metabolic pathologies. Physical exercise is …

Context: The myokine irisin may increase energy expenditure and affect metabolism.
Objective: The objective of the study was to elucidate predictors of irisin and study whether …

The long-term effect of therapeutic diets in obesity treatment is a challenge at present. The
current study aimed to evaluate the long-term effect of a very low-calorie-ketogenic (VLCK) …