Abstract The p21-Activated kinase 1 (PAK1), a member of serine-threonine kinases family,
was initially identified as an interactor of the Rho GTPases RAC1 and CDC42, which affect a …

MircoRNAs (miRNAs) are a diverse family of highly-conserved small non-coding RNAs,
which range from approximately 18 to 25 nucleotides in size. They regulate gene expression …

MicroRNAs are post-transcriptional mediators of gene expression and regulation, which play
influential roles in tumorigenesis and cancer metastasis. The expression of tumor …

Bladder cancer (BC) is the fifth most common cancer worldwide and is associated with
significant morbidity and mortality. The prognosis of muscle invasive BC is poor, and …

miRNAs are single-stranded small RNAs that do not encode proteins. They can combine
complementarily with the 3′-UTRs of target gene mRNA molecules to promote targeted …

Studies have demonstrated low expression of miR-145 associated with cell proliferation and
migration in a wide variety of tumors. Here, we studied the expression of miR-145 in relation …

A thorough understanding of the tumor environment and underlying genetic factors helps in
the better formulation of cancer management strategies. Availability of efficient diagnostic …

Background: Hypoxia leads to the stabilisation of the hypoxia-inducible factor (HIF)
transcription factor that drives the expression of target genes including microRNAs …

Background The study was aimed to investigate the influence of circ_0058063 on
tumorigenesis as well as the regulatory mechanism of circ_0058063/miR‐145‐5p/CDK6 …

Since the initial recognition of a mechanistic role of p21-activated kinase 1 (PAK1) in breast
cancer invasion, PAK1 has emerged as one of the widely overexpressed or hyperactivated …