Greater than 80% of malaria-related mortality occurs in sub-Saharan Africa due to infections
with Plasmodium falciparum. The majority of P. falciparum-related mortality occurs in …

Coevolution of humans and malaria parasites has generated an intricate balance between
the immune system of the host and virulence factors of the parasite, equilibrating maximal …

Background Zoonotic malaria caused by Plasmodium knowlesi is an important, but newly
recognized, human pathogen. For the first time, post-mortem findings from a fatal case of …

Malaria is a deadly infectious disease caused by the intraerythrocytic protozoan parasite
Plasmodium. The four species of Plasmodium known to affect humans all produce an …

Recruitment and activation of monocytes and macrophages are essential for clearance of
malaria infection, but these have also been associated with adverse clinical outcomes. In …

While half of the world's population is at risk of malaria, the most vulnerable are still children
under five, pregnant women and returning travelers. Anopheles mosquitoes transmit malaria …

Macrophage migration inhibitory factor (MIF) is a pleiotropic cytokine produced by the
pituitary gland and multiple cell types, including macrophages (Mø), dendritic cells (DC) and …

Abstract Background The simian parasite Plasmodium knowlesi is recognized as a common
cause of severe and fatal human malaria in Sabah, Malaysia, but is morphologically …

Severe malarial anemia is the most common syndrome of severe malaria in endemic areas.
The pathophysiology of chronic malaria is characterised by a striking degree of abnormal …

Severe malaria anemia is characterized by inhibited/altered erythropoiesis and presence of
hemozoin-(HZ)-laden bone-marrow macrophages. HZ mediates peroxidation of unsaturated …