The relative insufficiency of insulin secretion and/or insulin action causes diabetes.
However, obesity and type 2 diabetes mellitus can be associated with an absolute increase …

Although several early phase clinical trials raised enthusiasm for the use of insulin-like
growth factor I receptor (IGF1R)-specific antibodies for cancer treatment, initial Phase III …

Studies in invertebrates have led to the identification of a number of genes that regulate
lifespan, some of which encode components of the insulin or insulin-like signalling …

Insulin resistance, recently recognized as a strong predictor of disease in adults, has
become the leading element of the metabolic syndrome and renewed as a focus of …

Altered growth and development of the endocrine pancreas is a frequent cause of the
hyperglycemia associated with diabetes. Here we show that microRNA-375 (miR-375) …

The insulin-like growth factor (IGF) signaling pathway consists of multiple IGF ligands, IGF
receptors, and IGF-binding proteins (IGFBPs). Studies in a variety of animal and cellular …

Forkhead proteins, and FoxO1 in particular, play a significant role in regulating whole body
energy metabolism. Glucose homeostasis is achieved by adjusting endogenous glucose …

IGF-I is expressed in virtually every tissue of the body, but with much higher expression in
the liver than in any other tissue. Studies using mice with liver-specific IGF-I knockout have …

It is now well accepted that diabetes mellitus is one of the main threats to human health in
the twenty-first century. The total number of people with diabetes worldwide was estimated …

The progressive loss of pancreatic β‐cell mass that occurs in both type 1 and type 2
diabetes is a primary factor driving efforts to identify strategies for effectively increasing …