Background: The American Heart Association, in conjunction with the National Institutes of
Health, annually reports the most up-to-date statistics related to heart disease, stroke, and …

BACKGROUND: The American Heart Association (AHA), in conjunction with the National
Institutes of Health, annually reports the most up-to-date statistics related to heart disease …

As populations age worldwide, the burden of valvular heart disease has grown
exponentially, and so has the proportion of affected women. Although rheumatic valve …

Thoracic aortic aneurysm and dissection (TAAD) affects many patients globally and has high
mortality rates if undetected. Once thought to be solely a degenerative disease that afflicted …

Inherited thoracic aortopathies denote a group of congenital conditions that predispose to
disease of the thoracic aorta. Aortic wall weakness and abnormal aortic hemodynamic …

Background: Myocardial infarction (MI) induces an intense injury response that ultimately
generates a collagen-dominated scar. Although required to prevent ventricular rupture, the …

Bicuspid aortic valve (BAV) is the most common congenital heart defect, found in up to 2% of
the population and associated with a 30% lifetime risk of complications. BAV is inherited as …

Thoracic aortic aneurysm is a typically silent disease characterized by a lethal natural
history. Since the discovery of the familial nature of thoracic aortic aneurysm and dissection …

BACKGROUND: Although single-cell RNA-sequencing is commonly applied to dissect the
heterogeneity in human tissues, it involves the preparation of single-cell suspensions via …

Aims The present study aims to characterize the genetic risk architecture of bicuspid aortic
valve (BAV) disease, the most common congenital heart defect. Methods and results We …