The risk assessment of chemical carcinogens is one major task in toxicology. Even though
exposure has been mitigated effectively during the last decades, low levels of carcinogenic …

The designation of acetaldehyde associated with the consumption of alcoholic beverages as
“carcinogenic to humans”(Group 1) by the International Agency for Research on Cancer …

The IARC Perspective on Alcohol Reduction or Cessation and Cancer Risk | New England
Journal of Medicine Skip to main content The New England Journal of Medicine homepage …

Alcohol is classified by the International Agency for Research on Cancer (IARC) as a human
carcinogen and its consumption has been associated to an increased risk of liver, breast …

Head and neck cancer (HNC) concerns more than 890,000 patients worldwide annually and
is associated with the advanced stage at presentation and heavy outcomes. Alcohol …

Acetaldehyde is a highly reactive compound that causes various forms of damage to DNA,
including DNA adducts, single-and/or double-strand breaks (DSBs), point mutations, sister …

DNA adducts are believed to play a central role in the induction of cancer in cigarette
smokers and are proposed as being potential biomarkers of cancer risk. We have …

Background Oral and pharynx cancer represent a serious global problem, reaching an
incidence of half a million cases annually. The role of tobacco and alcohol have been …

Exposure to endogenous and exogenous chemicals can lead to the formation of structurally
modified DNA bases (DNA adducts). If not repaired, these nucleobase lesions can cause …

The resident microbiome plays a key role in exposure of the upper gastrointestinal (GI) tract
mucosa to acetaldehyde (ACH), a carcinogenic metabolite of ethanol. Poor oral health is a …