Diffuse glioma heterogeneity and its therapeutic implications

JG Nicholson, HA Fine - Cancer discovery, 2021 - AACR
Diffuse gliomas represent a heterogeneous group of universally lethal brain tumors
characterized by minimally effective genotype-targeted therapies. Recent advances have …

Up-down regulation of HIF-1α in cancer progression

M Rashid, LR Zadeh, B Baradaran, O Molavi… - Gene, 2021 - Elsevier
Hypoxia induicible factor-1 alpha (HIF-1α) is a key transcription factor in cancer progression
and target therapy in cancer. HIF-1α acts differently depending on presence or absence of …

Glioblastoma stem cells: driving resilience through chaos

BC Prager, S Bhargava, V Mahadev, CG Hubert… - Trends in cancer, 2020 - cell.com
Glioblastoma is an aggressive and heterogeneous tumor in which glioblastoma stem cells
(GSCs) are at the apex of an entropic hierarchy and impart devastating therapy resistance …

[HTML][HTML] Therapeutic targeting of hypoxia and hypoxia-inducible factors in cancer

C Wigerup, S Påhlman, D Bexell - Pharmacology & therapeutics, 2016 - Elsevier
Insufficient tissue oxygenation, or hypoxia, contributes to tumor aggressiveness and has a
profound impact on clinical outcomes in cancer patients. At decreased oxygen tensions …

Pharmacologic targeting of hypoxia-inducible factors

GL Semenza - Annual review of pharmacology and toxicology, 2019 - annualreviews.org
Hypoxia-inducible factors (HIFs) control transcriptional responses to reduced O2 availability.
HIFs are heterodimeric proteins composed of an O2-regulated HIF-α subunit and a …

Hypoxia: a key player in antitumor immune response. A review in the theme: cellular responses to hypoxia

MZ Noman, M Hasmim, Y Messai… - … of Physiology-Cell …, 2015 - journals.physiology.org
The tumor microenvironment is a complex system, playing an important role in tumor
development and progression. Besides cellular stromal components, extracellular matrix …

[HTML][HTML] Oxygen in stem cell biology: a critical component of the stem cell niche

A Mohyeldin, T Garzón-Muvdi, A Quiñones-Hinojosa - Cell stem cell, 2010 - cell.com
The defining hallmark of stem cells is their ability to self-renew and maintain multipotency.
This capacity depends on the balance of complex signals in their microenvironment. Low …

Improving cancer immunotherapy by targeting the hypoxic tumor microenvironment: new opportunities and challenges

MZ Noman, M Hasmim, A Lequeux, M Xiao, C Duhem… - Cells, 2019 - mdpi.com
Initially believed to be a disease of deregulated cellular and genetic expression, cancer is
now also considered a disease of the tumor microenvironment. Over the past two decades …

Mitochondria and metabolic transitions in cardiomyocytes: lessons from development for stem cell-derived cardiomyocytes

JC Garbern, RT Lee - Stem Cell Research & Therapy, 2021 - Springer
Current methods to differentiate cardiomyocytes from human pluripotent stem cells (PSCs)
inadequately recapitulate complete development and result in PSC-derived cardiomyocytes …

Transcription factors in cancer development and therapy

K Vishnoi, N Viswakarma, A Rana, B Rana - Cancers, 2020 - mdpi.com
Cancer is a multi-step process and requires constitutive expression/activation of
transcription factors (TFs) for growth and survival. Many of the TFs reported so far are critical …