Inflammasomes are cytoplasmic multiprotein complexes comprising a sensor protein,
inflammatory caspases, and in some but not all cases an adapter protein connecting the two …

Endoplasmic reticulum stress (ERS) is a protective response to restore protein homeostasis
by activating the unfolded protein response (UPR). However, UPR can trigger cell death …

Autophagy, apoptosis, and the unfolded protein response (UPR) are fundamental biological
processes essential for manifold cellular functions in health and disease. Idiopathic …

Copper (Cu) is a common additive in food products, which poses a potential concern to
animal and human health when it is in excess. Here, we investigated the relationship …

The NLRP3 (nucleotide-binding domain, leucine-rich-repeat-containing family, pyrin domain-
containing 3) inflammasome senses pathogen-associated molecular patterns (PAMPs) and …

Neuronal death and inflammatory response are two common pathological hallmarks of
acute central nervous system injury and chronic degenerative disorders, both of which are …

Background Recently, depression has been identified as a prevalent and severe mental
disorder. However, the mechanisms underlying the depression risk remain elusive. The …

In December 2019, many pneumonia cases with unidentified sources appeared in Wuhan,
Hubei, China, with clinical symptoms like viral pneumonia. Deep sequencing analysis of …

Type I interferonopathies cover a phenotypically heterogeneous group of rare genetic
diseases including the recently described proteasome-associated autoinflammatory …

Acrylamide (AA) in heat-processed food leads to widespread concerns due to its
hepatotoxicity. Allicin, a plant-derived antioxidant, possesses a significant protective effect …