Abstract Cys2His2 (C2H2)-type zinc fingers are widespread DNA binding motifs in
eukaryotic transcription factors. Zinc fingers are short protein motifs composed of two or …

The BTB/POZ-ZF [Broad complex, Tramtrack, Bric à brac (BTB) or poxvirus and zinc finger
(POZ)-zinc finger] protein family comprises a diverse group of transcription factors. POZ-ZF …

Fanconi anemia is a rare autosomal recessive disease characterized by bone marrow
failure, developmental anomalies, a high incidence of myelodysplasia and acute …

The promyelocytic leukemia zinc finger (PLZF) protein, also known as Zbtb16 or Zfp145, was
first identified in a patient with acute promyelocytic leukemia, where a reciprocal …

Cancer treatments regimes which include conventional chemotherapy have not proved so
successful in curing human malignancies. Failures to these treatment modalities include …

The catenin p120 (hereafter p120ctn) was first identified as a Src kinase substrate and
subsequently characterized as an Armadillo catenin member of the cell–cell adhesion …

The transcriptional repressor PLZF was identified by its translocation with retinoic acid
receptor alpha in t (11; 17) acute promyelocytic leukemia (APL). Ectopic expression of PLZF …

Background Breast cancer remains in urgent need of reliable diagnostic and prognostic
markers. Zinc finger and BTB/POZ domain-containing family proteins (ZBTBs) are important …

Successful immunity depends upon the activity of multiple cell types. Commitment of
pluripotent precursor cells to specific lineages, such as T or B cells, is obviously fundamental …

Abstract CIITA and MHC class II expression is silenced during the differentiation of B cells to
plasma cells. When B cell differentiation is carried out ex vivo, CIITA silencing occurs rapidly …